Cargando…

Staged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrins

BACKGROUND: Interactions between cancer cells and stroma are critical for growth and invasiveness of epithelial tumors. The biochemical mechanisms behind tumor-stromal interactions leading to increased invasiveness and metastasis are mostly unknown. The goal of this study was to analyze the direct e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Castelló-Cros, Remedios, Khan, David R, Simons, Jeffrey, Valianou, Matthildi, Cukierman, Edna
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669806/ https://www.ncbi.nlm.nih.gov/pubmed/19323811 http://dx.doi.org/10.1186/1471-2407-9-94

Ejemplares similares

FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells
por: Lee, Hyung-Ok, et al.
Publicado: (2011)

Pharmacological inhibition of Polo-like kinase 1 (PLK1) by BI-2536 decreases the viability and survival of hamartin and tuberin deficient cells via induction of apoptosis and attenuation of autophagy
por: Valianou, Matthildi, et al.
Publicado: (2015)

Integrin αIIb-Mediated PI3K/Akt Activation in Platelets
por: Niu, Haixia, et al.
Publicado: (2012)

Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins
por: Czekay, Ralf-Peter, et al.
Publicado: (2003)

PI3Kβ links integrin activation and PI(3,4)P(2) production during invadopodial maturation
por: Erami, Zahra, et al.
Publicado: (2019)

Mechanotransduction via the coordinated actions of integrins, PI3K signaling and Connexin hemichannels
por: Riquelme, Manuel A., et al.
Publicado: (2021)

Mesenchymal stromal cell-derived extracellular vesicles afford neuroprotection by modulating PI3K/AKT pathway and calcium oscillations
por: Turovsky, Egor A., et al.
Publicado: (2022)

Integrin beta 3-overexpressing mesenchymal stromal cells display enhanced homing and can reduce atherosclerotic plaque
por: Hu, Hai-Juan, et al.
Publicado: (2023)

Integrin beta 3 cytoplasmic tail is necessary and sufficient for regulation of alpha 5 beta 1 phagocytosis by alpha v beta 3 and integrin-associated protein
Publicado: (1995)

Stromal PTEN Regulates Extracellular Matrix Organization in the Mammary Gland()
por: Jones, Caitlin E., et al.
Publicado: (2018)

Targeting PI3K Signaling in Acute Lymphoblastic Leukemia
por: Sanchez, Vanessa Edna, et al.
Publicado: (2019)

Integrin β1 regulates marginal zone B cell differentiation and PI3K signaling
por: Andreani, Virginia, et al.
Publicado: (2022)

Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection
por: Pillinger, Genevra, et al.
Publicado: (2016)

Glioma Initiating Cells Form a Differentiation Niche Via the Induction of Extracellular Matrices and Integrin αV
por: Niibori-Nambu, Akiko, et al.
Publicado: (2013)

Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton
por: Adamo, Annalisa, et al.
Publicado: (2019)

Regulation of the PI3K/Akt pathway during decidualization of endometrial stromal cells
por: Fabi, François, et al.
Publicado: (2017)

The Role of Tumor Microenvironment in Chemoresistance: 3D Extracellular Matrices as Accomplices
por: Senthebane, Dimakatso Alice, et al.
Publicado: (2018)

Sustained hedgehog signaling in medulloblastoma tumoroids is attributed to stromal astrocytes and astrocyte-derived extracellular matrix
por: Cheng, Yan, et al.
Publicado: (2020)

Rapalog resistance is associated with mesenchymal-type changes in Tsc2-null cells
por: Valianou, Matthildi, et al.
Publicado: (2019)

PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosis
por: Wang, Peng, et al.
Publicado: (2023)

PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosis
por: Wang, Peng, et al.
Publicado: (2023)

Cytoplasmic and transmembrane domains of integrin beta 1 and beta 3 subunits are functionally interchangeable
Publicado: (1991)

Elevated Expression of Stromal Palladin Predicts Poor Clinical Outcome in Renal Cell Carcinoma
por: Gupta, Vivekanand, et al.
Publicado: (2011)

Interleukin-8 promotes integrin β3 upregulation and cell invasion through PI3K/Akt pathway in hepatocellular carcinoma
por: Sun, Fengkai, et al.
Publicado: (2019)

Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit
Publicado: (1995)

Synthetic Extracellular Matrices for 3D Culture of Schwann Cells, Hepatocytes, and HUVECs
por: Ma, Chiyuan, et al.
Publicado: (2022)

Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ
por: Uehara, Mayuko, et al.
Publicado: (2017)

Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation
por: Toricelli, Mariana, et al.
Publicado: (2013)

Transmembrane Collagen XVII Modulates Integrin Dependent Keratinocyte Migration via PI3K/Rac1 Signaling
por: Löffek, Stefanie, et al.
Publicado: (2014)

The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P(3)) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin α(IIb)β(3) Outside-in Signaling
por: Battram, Anthony M., et al.
Publicado: (2017)

Expression of beta 1, beta 3, beta 4, and beta 5 integrins by human epidermal keratinocytes and non-differentiating keratinocytes
Publicado: (1991)

The Effect of Stromal Integrin β3-Deficiency on Two Different Tumors in Mice
por: Reigstad, Inga, et al.
Publicado: (2016)

Nanocomposite Hydrogels as Functional Extracellular Matrices
por: Jooken, Stijn, et al.
Publicado: (2023)

CEBPD is a master transcriptional factor for hypoxia regulated proteins in glioblastoma and augments hypoxia induced invasion through extracellular matrix-integrin mediated EGFR/PI3K pathway
por: Mao, Xing-gang, et al.
Publicado: (2023)

$\pi \pi$ scattering lengths and $K \to 3\pi$ decays
por: Gallorini, Stefano
Publicado: (2013)

Integrin Dynamics and Matrix Assembly: Tensin-Dependent Translocation of α(5)β(1) Integrins Promotes Early Fibronectin Fibrillogenesis
por: Pankov, Roumen, et al.
Publicado: (2000)

Erratum: Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation
por: Toricelli, Mariana, et al.
Publicado: (2015)

Stage-Dependent Activity and Pro-Chondrogenic Function of PI3K/AKT during Cartilage Neogenesis from Mesenchymal Stromal Cells
por: Klampfleuthner, Felicia A. M., et al.
Publicado: (2022)

Effects of Kindlin-2 on proliferation and migration of VSMC and integrinβ1 andβ3 activity via FAK-PI3K signaling pathway
por: Wu, Xiaolin, et al.
Publicado: (2020)

New Strategies to Extract $\beta$ and $\gamma$ from $B_{d} \to \pi^{+} \pi^{-}$ and $B_{s} \to K^{+} K^{-}$
por: Fleischer, Robert
Publicado: (1999)

Cannot write session to /tmp/vufind_sessions/sess_cjrs1acu9bv515e8u406ni1cnn