Cell Survival from Chemotherapy Depends on NF-κB Transcriptional Up-Regulation of Coenzyme Q Biosynthesis

BACKGROUND: Coenzyme Q (CoQ) is a lipophilic antioxidant that is synthesized by a mitochondrial complex integrated by at least ten nuclear encoded COQ gene products. CoQ increases cell survival under different stress conditions, including mitochondrial DNA (mtDNA) depletion and treatment with cancer...

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Detalles Bibliográficos
Autores principales: Brea-Calvo, Gloria, Siendones, Emilio, Sánchez-Alcázar, José A., de Cabo, Rafael, Navas, Plácido
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669882/
https://www.ncbi.nlm.nih.gov/pubmed/19390650
http://dx.doi.org/10.1371/journal.pone.0005301

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