Indirect Recruitment of a CD40 Signaling Pathway in Dendritic Cells by B7-DC Cross-Linking Antibody Modulates T Cell Functions

The human IgM B7-DC XAb protects mice from tumors in both therapeutic and prophylactic settings. Its mechanism of action is mediated by its binding to B7-DC/PD-L2 molecules on the surface of dendritic cells (DCs) to induce a multimolecular cap and subsequent activation of signaling cascades that det...

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Detalles Bibliográficos
Autores principales: Radhakrishnan, Suresh, Cabrera, Rosalyn, Bruns, Kristina M., Van Keulen, Virginia P., Hansen, Michael J., Felts, Sara J., Pease, Larry R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670496/
https://www.ncbi.nlm.nih.gov/pubmed/19399172
http://dx.doi.org/10.1371/journal.pone.0005373

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