Cargando…

alpha-Sarcin catalytic activity is not required for cytotoxicity

BACKGROUND: α-Sarcin is a protein toxin produced by Aspergillus giganteus. It belongs to a family of cytotoxic ribonucleases that inactivate the ribosome and inhibit protein synthesis. α-Sarcin cleaves a single phosphodiester bond within the RNA backbone of the large ribosomal subunit, which makes t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alford, Spencer C, Pearson, Joel D, Carette, Amanda, Ingham, Robert J, Howard, Perry L
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670844/ https://www.ncbi.nlm.nih.gov/pubmed/19344516 http://dx.doi.org/10.1186/1471-2091-10-9

Ejemplares similares

The ribotoxin α-sarcin can cleave the sarcin/ricin loop on late 60S pre-ribosomes
por: Olombrada, Miriam, et al.
Publicado: (2020)

Molecular dynamics simulations of sarcin–ricin rRNA motif
por: Špačková, Nad'a, et al.
Publicado: (2006)

Differences in Ribosome Binding and Sarcin/Ricin Loop Depurination by Shiga and Ricin Holotoxins
por: Li, Xiao-Ping, et al.
Publicado: (2017)

RNA Probes for Visualization of Sarcin/ricin Loop Depurination without Background Fluorescence
por: Klimek, Robin, et al.
Publicado: (2022)

Soluble ephrin a1 is necessary for the growth of HeLa and SK-BR3 cells
por: Alford, Spencer, et al.
Publicado: (2010)

Pharmacokinetic profile of sarcin and thionin from Aspergillus giganteus and in vitro validation against human fungal pathogen
por: Ravindhiran, Ramya, et al.
Publicado: (2022)

A deimmunised form of the ribotoxin, α-sarcin, lacking CD4(+) T cell epitopes and its use as an immunotoxin warhead
por: Jones, Tim D., et al.
Publicado: (2016)

Cleavage of the sarcin–ricin loop of 23S rRNA differentially affects EF-G and EF-Tu binding
por: García-Ortega, Lucía, et al.
Publicado: (2010)

Erratum: Differences in Ribosome Binding and Sarcin/Ricin Loop Depurination by Shiga and Ricin Holotoxins. Toxins 2017, 9, 133
por: Editorial Office, Toxins
Publicado: (2018)

Efficient in vivo antitumor effect of an immunotoxin based on ribotoxin α-sarcin in nude mice bearing human colorectal cancer xenografts
por: Tomé-Amat, Jaime, et al.
Publicado: (2015)

A New Optimized Version of a Colorectal Cancer-Targeted Immunotoxin Based on a Non-Immunogenic Variant of the Ribotoxin α-Sarcin
por: Narbona, Javier, et al.
Publicado: (2023)

Inclusion of a Furin Cleavage Site Enhances Antitumor Efficacy against Colorectal Cancer Cells of Ribotoxin α-Sarcin- or RNase T1-Based Immunotoxins
por: Ruiz-de-la-Herrán, Javier, et al.
Publicado: (2019)

Knockdown of AMP-activated protein kinase alpha 1 and alpha 2 catalytic subunits
por: Tangeman, Larissa, et al.
Publicado: (2012)

Protecting Pax6 3′ UTR from MicroRNA-7 Partially Restores PAX6 in Islets from an Aniridia Mouse Model
por: Yongblah, Kevin, et al.
Publicado: (2018)

The Alpha Subunit of Nitrile Hydratase Is Sufficient for Catalytic Activity and Post-Translational Modification
por: Nelp, Micah T., et al.
Publicado: (2014)

Structural requirement of Ntc77 for spliceosome activation and first catalytic step
por: Chen, Hsin-Chou, et al.
Publicado: (2014)

Green Adeptness in the Synthesis and Stabilization of Copper Nanoparticles: Catalytic, Antibacterial, Cytotoxicity, and Antioxidant Activities
por: Din, Muhammad Imran, et al.
Publicado: (2017)

Helper activity is required for the in vivo generation of cytotoxic T lymphocytes
por: Keene, J-A, et al.
Publicado: (1982)

Cytotoxic T-cell activation by polyribonucleotides: DNA synthesis is not required
Publicado: (1977)

The cytotoxin of Pseudomonas aeruginosa: Cytotoxicity requires proteolytic activation
por: Orlik-Eisel, Gabriele, et al.
Publicado: (1990)

Monoclonal Antibodies Targeting the Alpha-Exosite of Botulinum Neurotoxin Serotype/A Inhibit Catalytic Activity
por: Fan, Yongfeng, et al.
Publicado: (2015)

The catalytic activity of TCPTP is auto-regulated by its intrinsically disordered tail and activated by Integrin alpha-1
por: Singh, Jai Prakash, et al.
Publicado: (2022)

Cytotoxicity and apoptotic activities of alpha-, gamma- and delta-tocotrienol isomers on human cancer cells
por: Lim, Su-Wen, et al.
Publicado: (2014)

The heat shock protein-90 co-chaperone, Cyclophilin 40, promotes ALK-positive, anaplastic large cell lymphoma viability and its expression is regulated by the NPM-ALK oncoprotein
por: Pearson, Joel D, et al.
Publicado: (2012)

AlphaFold2 models of the active form of all 437 catalytically competent human protein kinase domains
por: Faezov, Bulat, et al.
Publicado: (2023)

Cellular and genetic restrictions in the immunoregulatory activity of alpha-fetoprotein. II. Alpha-fetoprotein-induced suppression of cytotoxic T lymphocyte development
Publicado: (1978)

Catalytic Nanoceria Are Preferentially Retained in the Rat Retina and Are Not Cytotoxic after Intravitreal Injection
por: Wong, Lily L., et al.
Publicado: (2013)

Substrate discrimination and quality control require each catalytic activity of TRAMP and the nuclear RNA exosome
por: Das, Mom, et al.
Publicado: (2021)

High estrogen receptor alpha activation confers resistance to estrogen deprivation and is required for therapeutic response to estrogen in breast cancer
por: Traphagen, Nicole A., et al.
Publicado: (2021)

Regulation of the catalytic function of topoisomerase II alpha through association with RNA
por: Park, Seung-Won, et al.
Publicado: (2008)

Biosynthesis of silver nanoparticles using Onosma sericeum Willd. and evaluation of their catalytic properties and antibacterial and cytotoxic activity
por: DOĞAN ÇALHAN, Selda, et al.
Publicado: (2020)

Secretion and N-Linked Glycosylation Are Required for Prostatic Acid Phosphatase Catalytic and Antinociceptive Activity
por: Hurt, Julie K., et al.
Publicado: (2012)

Quantitative and Temporal Requirements Revealed for Zap-70 Catalytic Activity During T Cell Development
por: Au-Yeung, Byron B., et al.
Publicado: (2014)

Dual Requirement of Cytokine and Activation Receptor Triggering for Cytotoxic Control of Murine Cytomegalovirus by NK Cells
por: Parikh, Bijal A., et al.
Publicado: (2015)

Differential requirements for the canonical NF-κB transcription factors c-REL and RELA during the generation and activation of mature B-cells
por: Milanovic, Maja, et al.
Publicado: (2016)

Comparative Study of the Cytotoxicity and Genotoxicity of Alpha- and Beta-Asarone
por: Unger, Pascal, et al.
Publicado: (2012)

Alpha- and Beta-Cyclodextrin Inclusion Complexes with 5-Fluorouracil: Characterization and Cytotoxic Activity Evaluation
por: Di Donato, Cristina, et al.
Publicado: (2016)

Correction: Catalytic Nanoceria Are Preferentially Retained in the Rat Retina and Are Not Cytotoxic after Intravitreal Injection
por: Wong, Lily L., et al.
Publicado: (2013)

NPM-ALK: The Prototypic Member of a Family of Oncogenic Fusion Tyrosine Kinases
por: Pearson, Joel D., et al.
Publicado: (2012)

An excess of catalytically required motions inhibits the scavenger decapping enzyme
por: Neu, Ancilla, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_70ptd8cnme5mdjtmcsn9p6fobo