Depletion of interfering antibodies in chronic hepatitis C patients and vaccinated chimpanzees reveals broad cross-genotype neutralizing activity

Using human immune globulins made from antihepatitis C virus (HCV)-positive plasma, we recently identified two antibody epitopes in the E2 protein at residues 412–426 (epitope I) and 434–446 (epitope II). Whereas epitope I is highly conserved among genotypes, epitope II varies. We discovered that ep...

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Detalles Bibliográficos
Autores principales: Zhang, Pei, Zhong, Lilin, Struble, Evi Budo, Watanabe, Hisayoshi, Kachko, Alla, Mihalik, Kathleen, Virata, Maria Luisa, Alter, Harvey J., Feinstone, Stephen, Major, Marian
Formato: Texto
Lenguaje:English
Publicado: National Academy of Sciences 2009
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670884/
https://www.ncbi.nlm.nih.gov/pubmed/19380744
http://dx.doi.org/10.1073/pnas.0902749106

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