Cargando…
Degradation of cAMP-Responsive Element–Binding Protein by the Ubiquitin-Proteasome Pathway Contributes to Glucotoxicity in β-Cells and Human Pancreatic Islets
OBJECTIVE: In type 2 diabetes, chronic hyperglycemia is detrimental to β-cells, causing apoptosis and impaired insulin secretion. The transcription factor cAMP-responsive element–binding protein (CREB) is crucial for β-cell survival and function. We investigated whether prolonged exposure of β-cells...
Autores principales: | Costes, Safia, Vandewalle, Brigitte, Tourrel-Cuzin, Cécile, Broca, Christophe, Linck, Nathalie, Bertrand, Gyslaine, Kerr-Conte, Julie, Portha, Bernard, Pattou, François, Bockaert, Joel, Dalle, Stéphane |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671045/ https://www.ncbi.nlm.nih.gov/pubmed/19223597 http://dx.doi.org/10.2337/db08-0926 |
Ejemplares similares
-
Proteasome Dysfunction Mediates High Glucose-Induced Apoptosis in Rodent Beta Cells and Human Islets
por: Broca, Christophe, et al.
Publicado: (2014) -
Correction: Proteasome Dysfunction Mediates High Glucose-Induced Apoptosis in Rodent Beta Cells and Human Islets
por: Broca, Christophe, et al.
Publicado: (2014) -
Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment
por: Ruiz, Lucie, et al.
Publicado: (2018) -
Activation of the GLP-1 Receptor Signalling Pathway: A Relevant Strategy to Repair a Deficient Beta-Cell Mass
por: Portha, Bernard, et al.
Publicado: (2011) -
The nuclear receptor REV-ERBα is implicated in the alteration of β-cell autophagy and survival under diabetogenic conditions
por: Brown, Matthew R., et al.
Publicado: (2022)