Specific Local Cardiovascular Changes of N(ɛ)-(Carboxymethyl)lysine, Vascular Endothelial Growth Factor, and Smad2 in the Developing Embryos Coincide With Maternal Diabetes–Induced Congenital Heart Defects

OBJECTIVE: Embryos exposed to a diabetic environment in utero have an increased risk to develop congenital heart malformations. The mechanism behind the teratogenicity of diabetes still remains enigmatic. Detrimental effects of glycation products in diabetic patients have been well documented. We th...

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Detalles Bibliográficos
Autores principales: Roest, Pauline A.M., Molin, Daniël G.M., Schalkwijk, Casper G., van Iperen, Liesbeth, Wentzel, Parri, Eriksson, Ulf J., Gittenberger-de Groot, Adriana C.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671058/
https://www.ncbi.nlm.nih.gov/pubmed/19188426
http://dx.doi.org/10.2337/db07-1016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671058/
https://www.ncbi.nlm.nih.gov/pubmed/19188426
http://dx.doi.org/10.2337/db07-1016

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