Dynamic Changes in Pancreatic Endocrine Cell Abundance, Distribution, and Function in Antigen-Induced and Spontaneous Autoimmune Diabetes

OBJECTIVE: Insulin deficiency in type 1 diabetes and in rodent autoimmune diabetes models is caused by β-cell–specific killing by autoreactive T-cells. Less is known about β-cell numbers and phenotype remaining at diabetes onset and the fate of other pancreatic endocrine cellular constituents. RESEA...

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Detalles Bibliográficos
Autores principales: Pechhold, Klaus, Zhu, Xiaolong, Harrison, Victor S., Lee, Janet, Chakrabarty, Sagarika, Koczwara, Kerstin, Gavrilova, Oksana, Harlan, David M.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671059/
https://www.ncbi.nlm.nih.gov/pubmed/19228810
http://dx.doi.org/10.2337/db08-0616

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