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Phobic Anxiety Is Associated With Higher Serum Concentrations of Adipokines and Cytokines in Women With Diabetes

OBJECTIVE: Phobic anxiety has been associated with increased risk of cardiovascular disease (CVD), but the underlying mechanisms are poorly understood. We aimed to determine whether associations of phobic anxiety with several known markers of CVD might be contributors. RESEARCH DESIGN AND METHODS: W...

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Autores principales: Brennan, Aoife M., Fargnoli, Jessica L., Williams, Catherine J., Li, Tricia, Willett, Walter, Kawachi, I., Qi, Lu, Hu, Frank B., Mantzoros, Christos S.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671103/
https://www.ncbi.nlm.nih.gov/pubmed/19223611
http://dx.doi.org/10.2337/dc08-1979
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author Brennan, Aoife M.
Fargnoli, Jessica L.
Williams, Catherine J.
Li, Tricia
Willett, Walter
Kawachi, I.
Qi, Lu
Hu, Frank B.
Mantzoros, Christos S.
author_facet Brennan, Aoife M.
Fargnoli, Jessica L.
Williams, Catherine J.
Li, Tricia
Willett, Walter
Kawachi, I.
Qi, Lu
Hu, Frank B.
Mantzoros, Christos S.
author_sort Brennan, Aoife M.
collection PubMed
description OBJECTIVE: Phobic anxiety has been associated with increased risk of cardiovascular disease (CVD), but the underlying mechanisms are poorly understood. We aimed to determine whether associations of phobic anxiety with several known markers of CVD might be contributors. RESEARCH DESIGN AND METHODS: We used a 16-point validated index (Crown-Crisp) measured in 1988 to categorize 984 women with type 2 diabetes from the Nurses' Health Study as having low, moderate, or high phobic anxiety. Groups were then compared for differences in adipokines (adiponectin and leptin), inflammatory markers (C-reactive protein and tumor necrosis factor [TNF]-α receptor II), and markers of endothelial function (sE-selectin, soluble intercellular adhesion molecule [sICAM]-1) measured on blood samples provided between 1989 and 1990. RESULTS: Higher levels of phobic anxiety were associated with higher BMI and lower education. Higher levels of phobic anxiety were also associated with higher leptin and soluble TNF-α receptor II in both crude analyses and after adjustment for potential confounders. sICAM and sE-selectin were higher in the highest tertile compared with the middle tertile, but there was no significant trend across tertiles. We found no association between phobic anxiety and adiponectin. CONCLUSIONS: High levels of phobic anxiety are associated with increased levels of leptin and inflammatory markers, which may in part explain the previously observed relationship between anxiety and other psychosocial disorders with CVD.
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spelling pubmed-26711032010-05-01 Phobic Anxiety Is Associated With Higher Serum Concentrations of Adipokines and Cytokines in Women With Diabetes Brennan, Aoife M. Fargnoli, Jessica L. Williams, Catherine J. Li, Tricia Willett, Walter Kawachi, I. Qi, Lu Hu, Frank B. Mantzoros, Christos S. Diabetes Care Original Research OBJECTIVE: Phobic anxiety has been associated with increased risk of cardiovascular disease (CVD), but the underlying mechanisms are poorly understood. We aimed to determine whether associations of phobic anxiety with several known markers of CVD might be contributors. RESEARCH DESIGN AND METHODS: We used a 16-point validated index (Crown-Crisp) measured in 1988 to categorize 984 women with type 2 diabetes from the Nurses' Health Study as having low, moderate, or high phobic anxiety. Groups were then compared for differences in adipokines (adiponectin and leptin), inflammatory markers (C-reactive protein and tumor necrosis factor [TNF]-α receptor II), and markers of endothelial function (sE-selectin, soluble intercellular adhesion molecule [sICAM]-1) measured on blood samples provided between 1989 and 1990. RESULTS: Higher levels of phobic anxiety were associated with higher BMI and lower education. Higher levels of phobic anxiety were also associated with higher leptin and soluble TNF-α receptor II in both crude analyses and after adjustment for potential confounders. sICAM and sE-selectin were higher in the highest tertile compared with the middle tertile, but there was no significant trend across tertiles. We found no association between phobic anxiety and adiponectin. CONCLUSIONS: High levels of phobic anxiety are associated with increased levels of leptin and inflammatory markers, which may in part explain the previously observed relationship between anxiety and other psychosocial disorders with CVD. American Diabetes Association 2009-05 2009-02-17 /pmc/articles/PMC2671103/ /pubmed/19223611 http://dx.doi.org/10.2337/dc08-1979 Text en © 2009 by the American Diabetes Association. https://creativecommons.org/licenses/by-nc-nd/3.0/Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ (https://creativecommons.org/licenses/by-nc-nd/3.0/) for details.
spellingShingle Original Research
Brennan, Aoife M.
Fargnoli, Jessica L.
Williams, Catherine J.
Li, Tricia
Willett, Walter
Kawachi, I.
Qi, Lu
Hu, Frank B.
Mantzoros, Christos S.
Phobic Anxiety Is Associated With Higher Serum Concentrations of Adipokines and Cytokines in Women With Diabetes
title Phobic Anxiety Is Associated With Higher Serum Concentrations of Adipokines and Cytokines in Women With Diabetes
title_full Phobic Anxiety Is Associated With Higher Serum Concentrations of Adipokines and Cytokines in Women With Diabetes
title_fullStr Phobic Anxiety Is Associated With Higher Serum Concentrations of Adipokines and Cytokines in Women With Diabetes
title_full_unstemmed Phobic Anxiety Is Associated With Higher Serum Concentrations of Adipokines and Cytokines in Women With Diabetes
title_short Phobic Anxiety Is Associated With Higher Serum Concentrations of Adipokines and Cytokines in Women With Diabetes
title_sort phobic anxiety is associated with higher serum concentrations of adipokines and cytokines in women with diabetes
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671103/
https://www.ncbi.nlm.nih.gov/pubmed/19223611
http://dx.doi.org/10.2337/dc08-1979
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