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Antitumor Activity and Mechanism of Action of the Cyclopenta[b]benzofuran, Silvestrol

BACKGROUND: Flavaglines are a family of natural products from the genus Aglaia that exhibit anti-cancer activity in vitro and in vivo and inhibit translation initiation. They have been shown to modulate the activity of eIF4A, the DEAD-box RNA helicase subunit of the eukaryotic initiation factor (eIF...

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Detalles Bibliográficos
Autores principales:	Cencic, Regina, Carrier, Marilyn, Galicia-Vázquez, Gabriela, Bordeleau, Marie-Eve, Sukarieh, Rami, Bourdeau, Annie, Brem, Brigitte, Teodoro, Jose G., Greger, Harald, Tremblay, Michel L., Porco, John A., Pelletier, Jerry
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671147/ https://www.ncbi.nlm.nih.gov/pubmed/19401772 http://dx.doi.org/10.1371/journal.pone.0005223

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