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Monomeric Bistability and the Role of Autoloops in Gene Regulation
Genetic toggle switches are widespread in gene regulatory networks (GRN). Bistability, namely the ability to choose among two different stable states, is an essential feature of switching and memory devices. Cells have many regulatory circuits able to provide bistability that endow a cell with effic...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Public Library of Science
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671156/ https://www.ncbi.nlm.nih.gov/pubmed/19404388 http://dx.doi.org/10.1371/journal.pone.0005399 |
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author | Widder, Stefanie Macía, Javier Solé, Ricard |
author_facet | Widder, Stefanie Macía, Javier Solé, Ricard |
author_sort | Widder, Stefanie |
collection | PubMed |
description | Genetic toggle switches are widespread in gene regulatory networks (GRN). Bistability, namely the ability to choose among two different stable states, is an essential feature of switching and memory devices. Cells have many regulatory circuits able to provide bistability that endow a cell with efficient and reliable switching between different physiological modes of operation. It is often assumed that negative feedbacks with cooperative binding (i.e. the formation of dimers or multimers) are a prerequisite for bistability. Here we analyze the relation between bistability in GRN under monomeric regulation and the role of autoloops under a deterministic setting. Using a simple geometric argument, we show analytically that bistability can also emerge without multimeric regulation, provided that at least one regulatory autoloop is present. |
format | Text |
id | pubmed-2671156 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-26711562009-04-30 Monomeric Bistability and the Role of Autoloops in Gene Regulation Widder, Stefanie Macía, Javier Solé, Ricard PLoS One Research Article Genetic toggle switches are widespread in gene regulatory networks (GRN). Bistability, namely the ability to choose among two different stable states, is an essential feature of switching and memory devices. Cells have many regulatory circuits able to provide bistability that endow a cell with efficient and reliable switching between different physiological modes of operation. It is often assumed that negative feedbacks with cooperative binding (i.e. the formation of dimers or multimers) are a prerequisite for bistability. Here we analyze the relation between bistability in GRN under monomeric regulation and the role of autoloops under a deterministic setting. Using a simple geometric argument, we show analytically that bistability can also emerge without multimeric regulation, provided that at least one regulatory autoloop is present. Public Library of Science 2009-04-30 /pmc/articles/PMC2671156/ /pubmed/19404388 http://dx.doi.org/10.1371/journal.pone.0005399 Text en Widder et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Widder, Stefanie Macía, Javier Solé, Ricard Monomeric Bistability and the Role of Autoloops in Gene Regulation |
title | Monomeric Bistability and the Role of Autoloops in Gene Regulation |
title_full | Monomeric Bistability and the Role of Autoloops in Gene Regulation |
title_fullStr | Monomeric Bistability and the Role of Autoloops in Gene Regulation |
title_full_unstemmed | Monomeric Bistability and the Role of Autoloops in Gene Regulation |
title_short | Monomeric Bistability and the Role of Autoloops in Gene Regulation |
title_sort | monomeric bistability and the role of autoloops in gene regulation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671156/ https://www.ncbi.nlm.nih.gov/pubmed/19404388 http://dx.doi.org/10.1371/journal.pone.0005399 |
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