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Hantavirus Pulmonary Syndrome, Central Plateau, Southeastern, and Southern Brazil
Hantavirus pulmonary syndrome (HPS) is an increasing health problem in Brazil because of encroachment of sprawling urban, agricultural, and cattle-raising areas into habitats of subfamily Sigmodontinae rodents, which serve as hantavirus reservoirs. From 1993 through June 2007, a total of 884 cases o...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Centers for Disease Control and Prevention
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671436/ https://www.ncbi.nlm.nih.gov/pubmed/19331732 http://dx.doi.org/10.3201/eid1504.080289 |
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author | Figueiredo, Luiz T.M. Moreli, Marcos L. de Sousa, Ricardo L.M. Borges, Alessandra A. de Figueiredo, Glauciane G. Machado, Alex M. Bisordi, Ivani Nagasse-Sugahara, Teresa K. Suzuki, Akemi Pereira, Luiz E. de Souza, Renato P. de Souza, Luiza T.M. Braconi, Carla T. Harsi, Charlotte M. Zanotto, Paolo M. de Andrade |
author_facet | Figueiredo, Luiz T.M. Moreli, Marcos L. de Sousa, Ricardo L.M. Borges, Alessandra A. de Figueiredo, Glauciane G. Machado, Alex M. Bisordi, Ivani Nagasse-Sugahara, Teresa K. Suzuki, Akemi Pereira, Luiz E. de Souza, Renato P. de Souza, Luiza T.M. Braconi, Carla T. Harsi, Charlotte M. Zanotto, Paolo M. de Andrade |
author_sort | Figueiredo, Luiz T.M. |
collection | PubMed |
description | Hantavirus pulmonary syndrome (HPS) is an increasing health problem in Brazil because of encroachment of sprawling urban, agricultural, and cattle-raising areas into habitats of subfamily Sigmodontinae rodents, which serve as hantavirus reservoirs. From 1993 through June 2007, a total of 884 cases of HPS were reported in Brazil (case-fatality rate 39%). To better understand this emerging disease, we collected 89 human serum samples and 68 rodent lung samples containing antibodies to hantavirus from a 2,500-km-wide area in Brazil. RNA was isolated from human samples and rodent tissues and subjected to reverse transcription–PCR. Partial sequences of nucleocapsid protein and glycoprotein genes from 22 human and 16 rodent sources indicated only Araraquara virus and Juquitiba virus lineages. The case-fatality rate of HPS was higher in the area with Araraquara virus. This virus, which may be the most virulent hantavirus in Brazil, was associated with areas that have had greater anthropogenic changes. |
format | Text |
id | pubmed-2671436 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-26714362009-05-21 Hantavirus Pulmonary Syndrome, Central Plateau, Southeastern, and Southern Brazil Figueiredo, Luiz T.M. Moreli, Marcos L. de Sousa, Ricardo L.M. Borges, Alessandra A. de Figueiredo, Glauciane G. Machado, Alex M. Bisordi, Ivani Nagasse-Sugahara, Teresa K. Suzuki, Akemi Pereira, Luiz E. de Souza, Renato P. de Souza, Luiza T.M. Braconi, Carla T. Harsi, Charlotte M. Zanotto, Paolo M. de Andrade Emerg Infect Dis Research Hantavirus pulmonary syndrome (HPS) is an increasing health problem in Brazil because of encroachment of sprawling urban, agricultural, and cattle-raising areas into habitats of subfamily Sigmodontinae rodents, which serve as hantavirus reservoirs. From 1993 through June 2007, a total of 884 cases of HPS were reported in Brazil (case-fatality rate 39%). To better understand this emerging disease, we collected 89 human serum samples and 68 rodent lung samples containing antibodies to hantavirus from a 2,500-km-wide area in Brazil. RNA was isolated from human samples and rodent tissues and subjected to reverse transcription–PCR. Partial sequences of nucleocapsid protein and glycoprotein genes from 22 human and 16 rodent sources indicated only Araraquara virus and Juquitiba virus lineages. The case-fatality rate of HPS was higher in the area with Araraquara virus. This virus, which may be the most virulent hantavirus in Brazil, was associated with areas that have had greater anthropogenic changes. Centers for Disease Control and Prevention 2009-04 /pmc/articles/PMC2671436/ /pubmed/19331732 http://dx.doi.org/10.3201/eid1504.080289 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Figueiredo, Luiz T.M. Moreli, Marcos L. de Sousa, Ricardo L.M. Borges, Alessandra A. de Figueiredo, Glauciane G. Machado, Alex M. Bisordi, Ivani Nagasse-Sugahara, Teresa K. Suzuki, Akemi Pereira, Luiz E. de Souza, Renato P. de Souza, Luiza T.M. Braconi, Carla T. Harsi, Charlotte M. Zanotto, Paolo M. de Andrade Hantavirus Pulmonary Syndrome, Central Plateau, Southeastern, and Southern Brazil |
title | Hantavirus Pulmonary Syndrome, Central Plateau, Southeastern, and Southern Brazil |
title_full | Hantavirus Pulmonary Syndrome, Central Plateau, Southeastern, and Southern Brazil |
title_fullStr | Hantavirus Pulmonary Syndrome, Central Plateau, Southeastern, and Southern Brazil |
title_full_unstemmed | Hantavirus Pulmonary Syndrome, Central Plateau, Southeastern, and Southern Brazil |
title_short | Hantavirus Pulmonary Syndrome, Central Plateau, Southeastern, and Southern Brazil |
title_sort | hantavirus pulmonary syndrome, central plateau, southeastern, and southern brazil |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671436/ https://www.ncbi.nlm.nih.gov/pubmed/19331732 http://dx.doi.org/10.3201/eid1504.080289 |
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