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Base Excision by Thymine DNA Glycosylase Mediates DNA-Directed Cytotoxicity of 5-Fluorouracil

5-Fluorouracil (5-FU), a chemotherapeutic drug commonly used in cancer treatment, imbalances nucleotide pools, thereby favoring misincorporation of uracil and 5-FU into genomic DNA. The processing of these bases by DNA repair activities was proposed to cause DNA-directed cytotoxicity, but the underl...

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Detalles Bibliográficos
Autores principales:	Kunz, Christophe, Focke, Frauke, Saito, Yusuke, Schuermann, David, Lettieri, Teresa, Selfridge, Jim, Schär, Primo
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671560/ https://www.ncbi.nlm.nih.gov/pubmed/19402749 http://dx.doi.org/10.1371/journal.pbio.1000091

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