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Structural and Functional Analyses of PAS Domain Interactions of the Clock Proteins Drosophila PERIOD and Mouse PERIOD2

PERIOD proteins are central components of the Drosophila and mammalian circadian clocks. The crystal structure of a Drosophila PERIOD (dPER) fragment comprising two PER-ARNT-SIM (PAS) domains (PAS-A and PAS-B) and two additional C-terminal α-helices (αE and αF) has revealed a homodimer mediated by i...

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Detalles Bibliográficos
Autores principales:	Hennig, Sven, Strauss, Holger M, Vanselow, Katja, Yildiz, Özkan, Schulze, Sabrina, Arens, Julia, Kramer, Achim, Wolf, Eva
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671562/ https://www.ncbi.nlm.nih.gov/pubmed/19402751 http://dx.doi.org/10.1371/journal.pbio.1000094

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