Cargando…
Early Sensorineural Hearing Loss in Ob/Ob Mouse, an Animal Model of Type 2 Diabetes
OBJECTIVES: There have been many studies on the relationship between diabetes mellitus and presbycusis. Microangiopathy and neuropathy that's caused by chronic hyperglycemia may lead to damage to the inner ear. Several clinical studies on humans and animal studies have been performed to investi...
Autores principales: | , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Otorhinolaryngology-Head and Neck Surgery
2008
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671764/ https://www.ncbi.nlm.nih.gov/pubmed/19434270 http://dx.doi.org/10.3342/ceo.2008.1.4.211 |
_version_ | 1782166423334813696 |
---|---|
author | Lee, Hyun-Seok Kim, Ki Ryung Chung, Won-Ho Cho, Yang-Sun Hong, Sung Hwa |
author_facet | Lee, Hyun-Seok Kim, Ki Ryung Chung, Won-Ho Cho, Yang-Sun Hong, Sung Hwa |
author_sort | Lee, Hyun-Seok |
collection | PubMed |
description | OBJECTIVES: There have been many studies on the relationship between diabetes mellitus and presbycusis. Microangiopathy and neuropathy that's caused by chronic hyperglycemia may lead to damage to the inner ear. Several clinical studies on humans and animal studies have been performed to investigate the association between diabetes and hearing loss, however, this relationship is still a matter of debate. We investigated the association of diabetes and sensorineural hearing loss in an animal model of type-2 diabetes and obesity (the ob/ob mouse [OM]). METHODS: The auditory brainstem response (ABR) thresholds were obtained in the OM and the wild type mice (C57BL/6J mice) up to 25 weeks after birth. After the animals were sacrificed, their cochleae were retrieved and then subjected to histopathologic observations. RESULTS: The OM exhibited significantly elevated ABR thresholds at 21 weeks of age, yet the C57BL/6J mice exhibited no significant change until 25 weeks of age. On the histological findings, outer hair cell degeneration and loss of spiral ganglion cells were observed in the middle and basal turns of the OM. On the contrary, no degenerative change was observed until 25 weeks of age in the C57BL/6J mice. CONCLUSION: This study suggests that chronic hyperglycemia and obesity may lead to early sensorineural hearing loss. |
format | Text |
id | pubmed-2671764 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Korean Society of Otorhinolaryngology-Head and Neck Surgery |
record_format | MEDLINE/PubMed |
spelling | pubmed-26717642009-05-11 Early Sensorineural Hearing Loss in Ob/Ob Mouse, an Animal Model of Type 2 Diabetes Lee, Hyun-Seok Kim, Ki Ryung Chung, Won-Ho Cho, Yang-Sun Hong, Sung Hwa Clin Exp Otorhinolaryngol Original Article OBJECTIVES: There have been many studies on the relationship between diabetes mellitus and presbycusis. Microangiopathy and neuropathy that's caused by chronic hyperglycemia may lead to damage to the inner ear. Several clinical studies on humans and animal studies have been performed to investigate the association between diabetes and hearing loss, however, this relationship is still a matter of debate. We investigated the association of diabetes and sensorineural hearing loss in an animal model of type-2 diabetes and obesity (the ob/ob mouse [OM]). METHODS: The auditory brainstem response (ABR) thresholds were obtained in the OM and the wild type mice (C57BL/6J mice) up to 25 weeks after birth. After the animals were sacrificed, their cochleae were retrieved and then subjected to histopathologic observations. RESULTS: The OM exhibited significantly elevated ABR thresholds at 21 weeks of age, yet the C57BL/6J mice exhibited no significant change until 25 weeks of age. On the histological findings, outer hair cell degeneration and loss of spiral ganglion cells were observed in the middle and basal turns of the OM. On the contrary, no degenerative change was observed until 25 weeks of age in the C57BL/6J mice. CONCLUSION: This study suggests that chronic hyperglycemia and obesity may lead to early sensorineural hearing loss. Korean Society of Otorhinolaryngology-Head and Neck Surgery 2008-12 2008-12-26 /pmc/articles/PMC2671764/ /pubmed/19434270 http://dx.doi.org/10.3342/ceo.2008.1.4.211 Text en Copyright © 2008 Korean Society of Otorhinolaryngology-Head and Neck Surgery http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lee, Hyun-Seok Kim, Ki Ryung Chung, Won-Ho Cho, Yang-Sun Hong, Sung Hwa Early Sensorineural Hearing Loss in Ob/Ob Mouse, an Animal Model of Type 2 Diabetes |
title | Early Sensorineural Hearing Loss in Ob/Ob Mouse, an Animal Model of Type 2 Diabetes |
title_full | Early Sensorineural Hearing Loss in Ob/Ob Mouse, an Animal Model of Type 2 Diabetes |
title_fullStr | Early Sensorineural Hearing Loss in Ob/Ob Mouse, an Animal Model of Type 2 Diabetes |
title_full_unstemmed | Early Sensorineural Hearing Loss in Ob/Ob Mouse, an Animal Model of Type 2 Diabetes |
title_short | Early Sensorineural Hearing Loss in Ob/Ob Mouse, an Animal Model of Type 2 Diabetes |
title_sort | early sensorineural hearing loss in ob/ob mouse, an animal model of type 2 diabetes |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671764/ https://www.ncbi.nlm.nih.gov/pubmed/19434270 http://dx.doi.org/10.3342/ceo.2008.1.4.211 |
work_keys_str_mv | AT leehyunseok earlysensorineuralhearinglossinobobmouseananimalmodeloftype2diabetes AT kimkiryung earlysensorineuralhearinglossinobobmouseananimalmodeloftype2diabetes AT chungwonho earlysensorineuralhearinglossinobobmouseananimalmodeloftype2diabetes AT choyangsun earlysensorineuralhearinglossinobobmouseananimalmodeloftype2diabetes AT hongsunghwa earlysensorineuralhearinglossinobobmouseananimalmodeloftype2diabetes |