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The use of atypical antipsychotics beyond psychoses: efficacy of quetiapine in bipolar disorder

BACKGROUND AND RATIONALE: Atypical antpsychotics have been sucessfully used in the treatment of bipolar disorder (BD), either as adjunctive or as monotherapy. Quetiapine is an atypical antipsychotic extensively used in the treatment of psychotic disorders. It has serotonergic and dopaminergic activi...

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Autores principales: Mundo, Emanuela, Cattaneo, Elisabetta, Zanoni, Silvia, Altamura, A Carlo
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671777/
https://www.ncbi.nlm.nih.gov/pubmed/19412458
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author Mundo, Emanuela
Cattaneo, Elisabetta
Zanoni, Silvia
Altamura, A Carlo
author_facet Mundo, Emanuela
Cattaneo, Elisabetta
Zanoni, Silvia
Altamura, A Carlo
author_sort Mundo, Emanuela
collection PubMed
description BACKGROUND AND RATIONALE: Atypical antpsychotics have been sucessfully used in the treatment of bipolar disorder (BD), either as adjunctive or as monotherapy. Quetiapine is an atypical antipsychotic extensively used in the treatment of psychotic disorders. It has serotonergic and dopaminergic activity and it appears to be selective for the mesolimbic and mesocortical dopamine system. The aim of this paper was to review the recent literature on the use of quetiapine in the treatment of BD. METHODS: The literature databases currently available online were searched for papers on quetiapine and BD. Papers and reports published between January 1995 and June 2005 were selected and reviewed critically. RESULTS: Augmentative low dose quetiapine was found to be effective in BD partially responsive to conventional mood-stabilizers. Manic and mixed episodes have been the best studied, and quetiapine was found to be effective either as monotherapy or as adjunctive therapy in both randomized clinical trials and open-label studies. Data on the use of quetiapine in bipolar depression showed a significant efficacy and high remission rates. Maintenance data suggested a role of quetiapine as a good alternative to classical mood stabilizers in reducing recurrence rates of BD. A few studies on the efficacy in rapid cycling BD have also been published. CONCLUSIONS: Quetiapine is an effective agent for the short- and long-term treatment of BD. The mechanism of action of quetiapine as a mood stabilizer is still unknown. Some preliminary data suggest the involvement of glutamate pathways but further studies are needed to clarify this issue.
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spelling pubmed-26717772009-04-30 The use of atypical antipsychotics beyond psychoses: efficacy of quetiapine in bipolar disorder Mundo, Emanuela Cattaneo, Elisabetta Zanoni, Silvia Altamura, A Carlo Neuropsychiatr Dis Treat Expert Opinion BACKGROUND AND RATIONALE: Atypical antpsychotics have been sucessfully used in the treatment of bipolar disorder (BD), either as adjunctive or as monotherapy. Quetiapine is an atypical antipsychotic extensively used in the treatment of psychotic disorders. It has serotonergic and dopaminergic activity and it appears to be selective for the mesolimbic and mesocortical dopamine system. The aim of this paper was to review the recent literature on the use of quetiapine in the treatment of BD. METHODS: The literature databases currently available online were searched for papers on quetiapine and BD. Papers and reports published between January 1995 and June 2005 were selected and reviewed critically. RESULTS: Augmentative low dose quetiapine was found to be effective in BD partially responsive to conventional mood-stabilizers. Manic and mixed episodes have been the best studied, and quetiapine was found to be effective either as monotherapy or as adjunctive therapy in both randomized clinical trials and open-label studies. Data on the use of quetiapine in bipolar depression showed a significant efficacy and high remission rates. Maintenance data suggested a role of quetiapine as a good alternative to classical mood stabilizers in reducing recurrence rates of BD. A few studies on the efficacy in rapid cycling BD have also been published. CONCLUSIONS: Quetiapine is an effective agent for the short- and long-term treatment of BD. The mechanism of action of quetiapine as a mood stabilizer is still unknown. Some preliminary data suggest the involvement of glutamate pathways but further studies are needed to clarify this issue. Dove Medical Press 2006-06 /pmc/articles/PMC2671777/ /pubmed/19412458 Text en © 2006 Dove Medical Press Limited. All rights reserved
spellingShingle Expert Opinion
Mundo, Emanuela
Cattaneo, Elisabetta
Zanoni, Silvia
Altamura, A Carlo
The use of atypical antipsychotics beyond psychoses: efficacy of quetiapine in bipolar disorder
title The use of atypical antipsychotics beyond psychoses: efficacy of quetiapine in bipolar disorder
title_full The use of atypical antipsychotics beyond psychoses: efficacy of quetiapine in bipolar disorder
title_fullStr The use of atypical antipsychotics beyond psychoses: efficacy of quetiapine in bipolar disorder
title_full_unstemmed The use of atypical antipsychotics beyond psychoses: efficacy of quetiapine in bipolar disorder
title_short The use of atypical antipsychotics beyond psychoses: efficacy of quetiapine in bipolar disorder
title_sort use of atypical antipsychotics beyond psychoses: efficacy of quetiapine in bipolar disorder
topic Expert Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671777/
https://www.ncbi.nlm.nih.gov/pubmed/19412458
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