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Topiramate in the prevention of migraine: a review of its efficacy, tolerability, and acceptability
This paper reviews the results of placebo-controlled trials on topiramate (TPM) in the prophylaxis of migraine, focusing particularly on efficacy and tolerability of the target dose (100 mg/day). Data from well-conducted trials and analyses of pooled data show that TPM is effective against migraine,...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Dove Medical Press
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671823/ https://www.ncbi.nlm.nih.gov/pubmed/19412473 |
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author | D’Amico, Domenico Grazzi, Licia Bussone, Gennaro |
author_facet | D’Amico, Domenico Grazzi, Licia Bussone, Gennaro |
author_sort | D’Amico, Domenico |
collection | PubMed |
description | This paper reviews the results of placebo-controlled trials on topiramate (TPM) in the prophylaxis of migraine, focusing particularly on efficacy and tolerability of the target dose (100 mg/day). Data from well-conducted trials and analyses of pooled data show that TPM is effective against migraine, confirming the experience of physicians in various countries. High responder rate and good tolerability following slow titration suggest TPM as a first-line option for migraine prophylaxis. Patient acceptability may be enhanced by lack of weight gain, lack of major contraindications, and positive effects on quality of life. |
format | Text |
id | pubmed-2671823 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-26718232009-04-30 Topiramate in the prevention of migraine: a review of its efficacy, tolerability, and acceptability D’Amico, Domenico Grazzi, Licia Bussone, Gennaro Neuropsychiatr Dis Treat Expert Opinion This paper reviews the results of placebo-controlled trials on topiramate (TPM) in the prophylaxis of migraine, focusing particularly on efficacy and tolerability of the target dose (100 mg/day). Data from well-conducted trials and analyses of pooled data show that TPM is effective against migraine, confirming the experience of physicians in various countries. High responder rate and good tolerability following slow titration suggest TPM as a first-line option for migraine prophylaxis. Patient acceptability may be enhanced by lack of weight gain, lack of major contraindications, and positive effects on quality of life. Dove Medical Press 2006-09 /pmc/articles/PMC2671823/ /pubmed/19412473 Text en © 2006 Dove Medical Press Limited. All rights reserved |
spellingShingle | Expert Opinion D’Amico, Domenico Grazzi, Licia Bussone, Gennaro Topiramate in the prevention of migraine: a review of its efficacy, tolerability, and acceptability |
title | Topiramate in the prevention of migraine: a review of its efficacy, tolerability, and acceptability |
title_full | Topiramate in the prevention of migraine: a review of its efficacy, tolerability, and acceptability |
title_fullStr | Topiramate in the prevention of migraine: a review of its efficacy, tolerability, and acceptability |
title_full_unstemmed | Topiramate in the prevention of migraine: a review of its efficacy, tolerability, and acceptability |
title_short | Topiramate in the prevention of migraine: a review of its efficacy, tolerability, and acceptability |
title_sort | topiramate in the prevention of migraine: a review of its efficacy, tolerability, and acceptability |
topic | Expert Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671823/ https://www.ncbi.nlm.nih.gov/pubmed/19412473 |
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