Muscle Mitochondrial Uncoupling Dismantles Neuromuscular Junction and Triggers Distal Degeneration of Motor Neurons

BACKGROUND: Amyotrophic lateral sclerosis (ALS), the most frequent adult onset motor neuron disease, is associated with hypermetabolism linked to defects in muscle mitochondrial energy metabolism such as ATP depletion and increased oxygen consumption. It remains unknown whether muscle abnormalities...

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Detalles Bibliográficos
Autores principales: Dupuis, Luc, Gonzalez de Aguilar, Jose-Luis, Echaniz-Laguna, Andoni, Eschbach, Judith, Rene, Frédérique, Oudart, Hugues, Halter, Benoit, Huze, Caroline, Schaeffer, Laurent, Bouillaud, Frédéric, Loeffler, Jean-Philippe
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671839/
https://www.ncbi.nlm.nih.gov/pubmed/19404401
http://dx.doi.org/10.1371/journal.pone.0005390

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