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Complex topology rather than complex membership is a determinant of protein dosage sensitivity
The ‘balance hypothesis' predicts that non-stoichiometric variations in concentrations of proteins participating in complexes should be deleterious. As a corollary, heterozygous deletions and overexpression of protein complex members should have measurable fitness effects. However, genome-wide...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671925/ https://www.ncbi.nlm.nih.gov/pubmed/19293832 http://dx.doi.org/10.1038/msb.2009.9 |