Combining olfaction and cognition measures to screen for mild cognitive impairment

PURPOSE: This exploratory study examined the relationship between performance on the University of Pennsylvania Smell Identification Test (UPSIT) and the Addenbrooke’s Cognitive Examination (ACE) to identify a possible association between olfaction and mild cognitive impairment(MCI). DESIGN AND METH...

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Detalles Bibliográficos
Autores principales: Kirkpatrick, Mary Ann F, Combest, Wendell, Newton, Marian, Teske, Yvonne, Cavendish, John, McGee, Rhonda, Przychodzin, Danielle
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2006
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671946/
https://www.ncbi.nlm.nih.gov/pubmed/19412504
Descripción
Sumario:PURPOSE: This exploratory study examined the relationship between performance on the University of Pennsylvania Smell Identification Test (UPSIT) and the Addenbrooke’s Cognitive Examination (ACE) to identify a possible association between olfaction and mild cognitive impairment(MCI). DESIGN AND METHODS: 54 community-dwelling older (ages 49–91) volunteers were given the UPSIT and ACE. RESULTS: The ACE identified 7 subjects (13%) who had probable MCI. UPSIT total scores were significantly related to ACE total scores (r = 0.37, p = 0.005). Four specific odorants (mint, lime, chocolate, and cheddar cheese) from the UPSIT identified 4 of the 7 (57.1%) probable MCI subjects. The prevalence rate of MCI in subjects over 65 was 19.4%. IMPLICATIONS: Selective odorants in UPSIT used with ACE show promise as a non-invasive method of detecting MCI in community dwelling elders. Detection of MCI could facilitate earlier interventions and treatment of dementia.

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