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Does Quantitative Left Ventricular Regional Wall Motion Change after Fibrous Tissue Resection in Endomyocardial Fibrosis?

OBJECTIVES: We compared left ventricular regional wall motion, the global left ventricular ejection fraction, and the New York Heart Association functional class pre- and postoperatively. INTRODUCTION: Endomyocardial fibrosis is characterized by fibrous tissue deposition in the endomyocardium of the...

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Autores principales: Salemi, Vera Maria Cury, Fernandes, Fabio, Sirvente, Raquel, Nastari, Luciano, Rosa, Leonardo Vieira, Ferreira, Cristiano A., Pena, José Luiz Barros, Picard, Michael H., Mady, Charles
Formato: Texto
Lenguaje:English
Publicado: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671969/
https://www.ncbi.nlm.nih.gov/pubmed/19142546
http://dx.doi.org/10.1590/S1807-59322009000100004
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author Salemi, Vera Maria Cury
Fernandes, Fabio
Sirvente, Raquel
Nastari, Luciano
Rosa, Leonardo Vieira
Ferreira, Cristiano A.
Pena, José Luiz Barros
Picard, Michael H.
Mady, Charles
author_facet Salemi, Vera Maria Cury
Fernandes, Fabio
Sirvente, Raquel
Nastari, Luciano
Rosa, Leonardo Vieira
Ferreira, Cristiano A.
Pena, José Luiz Barros
Picard, Michael H.
Mady, Charles
author_sort Salemi, Vera Maria Cury
collection PubMed
description OBJECTIVES: We compared left ventricular regional wall motion, the global left ventricular ejection fraction, and the New York Heart Association functional class pre- and postoperatively. INTRODUCTION: Endomyocardial fibrosis is characterized by fibrous tissue deposition in the endomyocardium of the apex and/or inflow tract of one or both ventricles. Although left ventricular global systolic function is preserved, patients exhibit wall motion abnormalities in the apical and inferoapical regions. Fibrous tissue resection in New York Heart Association FC III and IV endomyocardial fibrosis patients has been shown to decrease morbidity and mortality. METHODS: We prospectively studied 30 patients (20 female, 30±10 years) before and 5±8 months after surgery. The left ventricular ejection fraction was determined using the area-length method. Regional left ventricular motion was measured by the centerline method. Five left ventricular segments were analyzed pre- and postoperatively. Abnormality was expressed in units of standard deviation from the mean motion in a normal reference population. RESULTS: Left ventricular wall motion in the five regions did not differ between pre- and postoperative measurements. Additionally, the left ventricular ejection fraction did not change after surgery (0.45±0.13% x 0.43±0.12% pre- and postoperatively, respectively). The New York Heart Association functional class improved to class I in 40% and class II in 43% of patients postoperatively (p<0.05). CONCLUSIONS: Although endomyocardial fibrosis patients have improved clinical symptoms after surgery, the global left ventricular ejection fraction and regional wall motion in these patients do not change. This finding suggests that other explanations, such as improvements in diastolic function, may be operational.
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spelling pubmed-26719692009-05-13 Does Quantitative Left Ventricular Regional Wall Motion Change after Fibrous Tissue Resection in Endomyocardial Fibrosis? Salemi, Vera Maria Cury Fernandes, Fabio Sirvente, Raquel Nastari, Luciano Rosa, Leonardo Vieira Ferreira, Cristiano A. Pena, José Luiz Barros Picard, Michael H. Mady, Charles Clinics (Sao Paulo) Clinical Science OBJECTIVES: We compared left ventricular regional wall motion, the global left ventricular ejection fraction, and the New York Heart Association functional class pre- and postoperatively. INTRODUCTION: Endomyocardial fibrosis is characterized by fibrous tissue deposition in the endomyocardium of the apex and/or inflow tract of one or both ventricles. Although left ventricular global systolic function is preserved, patients exhibit wall motion abnormalities in the apical and inferoapical regions. Fibrous tissue resection in New York Heart Association FC III and IV endomyocardial fibrosis patients has been shown to decrease morbidity and mortality. METHODS: We prospectively studied 30 patients (20 female, 30±10 years) before and 5±8 months after surgery. The left ventricular ejection fraction was determined using the area-length method. Regional left ventricular motion was measured by the centerline method. Five left ventricular segments were analyzed pre- and postoperatively. Abnormality was expressed in units of standard deviation from the mean motion in a normal reference population. RESULTS: Left ventricular wall motion in the five regions did not differ between pre- and postoperative measurements. Additionally, the left ventricular ejection fraction did not change after surgery (0.45±0.13% x 0.43±0.12% pre- and postoperatively, respectively). The New York Heart Association functional class improved to class I in 40% and class II in 43% of patients postoperatively (p<0.05). CONCLUSIONS: Although endomyocardial fibrosis patients have improved clinical symptoms after surgery, the global left ventricular ejection fraction and regional wall motion in these patients do not change. This finding suggests that other explanations, such as improvements in diastolic function, may be operational. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2009-01 /pmc/articles/PMC2671969/ /pubmed/19142546 http://dx.doi.org/10.1590/S1807-59322009000100004 Text en Copyright © 2009 Hospital das Clínicas da FMUSP
spellingShingle Clinical Science
Salemi, Vera Maria Cury
Fernandes, Fabio
Sirvente, Raquel
Nastari, Luciano
Rosa, Leonardo Vieira
Ferreira, Cristiano A.
Pena, José Luiz Barros
Picard, Michael H.
Mady, Charles
Does Quantitative Left Ventricular Regional Wall Motion Change after Fibrous Tissue Resection in Endomyocardial Fibrosis?
title Does Quantitative Left Ventricular Regional Wall Motion Change after Fibrous Tissue Resection in Endomyocardial Fibrosis?
title_full Does Quantitative Left Ventricular Regional Wall Motion Change after Fibrous Tissue Resection in Endomyocardial Fibrosis?
title_fullStr Does Quantitative Left Ventricular Regional Wall Motion Change after Fibrous Tissue Resection in Endomyocardial Fibrosis?
title_full_unstemmed Does Quantitative Left Ventricular Regional Wall Motion Change after Fibrous Tissue Resection in Endomyocardial Fibrosis?
title_short Does Quantitative Left Ventricular Regional Wall Motion Change after Fibrous Tissue Resection in Endomyocardial Fibrosis?
title_sort does quantitative left ventricular regional wall motion change after fibrous tissue resection in endomyocardial fibrosis?
topic Clinical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671969/
https://www.ncbi.nlm.nih.gov/pubmed/19142546
http://dx.doi.org/10.1590/S1807-59322009000100004
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