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Non-Asthmatic Patients Show Increased Exhaled Nitric Oxide Concentrations
OBJECTIVE: Evaluate whether exhaled nitric oxide may serve as a marker of intraoperative bronchospasm. INTRODUCTION: Intraoperative bronchospasm remains a challenging event during anesthesia. Previous studies in asthmatic patients suggest that exhaled nitric oxide may represent a noninvasive measure...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hospital das Clínicas da Faculdade de Medicina da Universidade
de São Paulo
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671975/ https://www.ncbi.nlm.nih.gov/pubmed/19142544 http://dx.doi.org/10.1590/S1807-59322009000100002 |
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author | Saraiva-Romanholo, Beatriz M. Machado, Fabio S. Almeida, Francine M. Nunes, Maria do Patrocínio T. Martins, Milton A. Vieira, Joaquim E. |
author_facet | Saraiva-Romanholo, Beatriz M. Machado, Fabio S. Almeida, Francine M. Nunes, Maria do Patrocínio T. Martins, Milton A. Vieira, Joaquim E. |
author_sort | Saraiva-Romanholo, Beatriz M. |
collection | PubMed |
description | OBJECTIVE: Evaluate whether exhaled nitric oxide may serve as a marker of intraoperative bronchospasm. INTRODUCTION: Intraoperative bronchospasm remains a challenging event during anesthesia. Previous studies in asthmatic patients suggest that exhaled nitric oxide may represent a noninvasive measure of airway inflammation. METHODS: A total of 146,358 anesthesia information forms, which were received during the period from 1999 to 2004, were reviewed. Bronchospasm was registered on 863 forms. From those, three groups were identified: 9 non-asthmatic patients (Bronchospasm group), 12 asthmatics (Asthma group) and 10 subjects with no previous airway disease or symptoms (Control group). All subjects were submitted to exhaled nitric oxide measurements (parts/billion), spirometry and the induced sputum test. The data was compared by ANOVA followed by the Tukey test and Kruskal-Wallis followed by Dunn’s test. RESULTS: The normal lung function test results for the Bronchospasm group were different from those of the asthma group (p <0.05). The median percentage of eosinophils in induced sputum was higher for the Asthma [2.46 (0.45–6.83)] compared with either the Bronchospasm [0.55 (0–1.26)] or the Control group [0.0 (0)] (p <0.05); exhaled nitric oxide followed a similar pattern for the Asthma [81.55 (57.6–86.85)], Bronchospasm [46.2 (42.0–62.6] and Control group [18.7 (16.0–24.7)] (p< 0.05). CONCLUSIONS: Non-asthmatic patients with intraoperative bronchospasm detected during anesthesia and endotracheal intubation showed increased expired nitric oxide. |
format | Text |
id | pubmed-2671975 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Hospital das Clínicas da Faculdade de Medicina da Universidade
de São Paulo |
record_format | MEDLINE/PubMed |
spelling | pubmed-26719752009-05-13 Non-Asthmatic Patients Show Increased Exhaled Nitric Oxide Concentrations Saraiva-Romanholo, Beatriz M. Machado, Fabio S. Almeida, Francine M. Nunes, Maria do Patrocínio T. Martins, Milton A. Vieira, Joaquim E. Clinics (Sao Paulo) Clinical Science OBJECTIVE: Evaluate whether exhaled nitric oxide may serve as a marker of intraoperative bronchospasm. INTRODUCTION: Intraoperative bronchospasm remains a challenging event during anesthesia. Previous studies in asthmatic patients suggest that exhaled nitric oxide may represent a noninvasive measure of airway inflammation. METHODS: A total of 146,358 anesthesia information forms, which were received during the period from 1999 to 2004, were reviewed. Bronchospasm was registered on 863 forms. From those, three groups were identified: 9 non-asthmatic patients (Bronchospasm group), 12 asthmatics (Asthma group) and 10 subjects with no previous airway disease or symptoms (Control group). All subjects were submitted to exhaled nitric oxide measurements (parts/billion), spirometry and the induced sputum test. The data was compared by ANOVA followed by the Tukey test and Kruskal-Wallis followed by Dunn’s test. RESULTS: The normal lung function test results for the Bronchospasm group were different from those of the asthma group (p <0.05). The median percentage of eosinophils in induced sputum was higher for the Asthma [2.46 (0.45–6.83)] compared with either the Bronchospasm [0.55 (0–1.26)] or the Control group [0.0 (0)] (p <0.05); exhaled nitric oxide followed a similar pattern for the Asthma [81.55 (57.6–86.85)], Bronchospasm [46.2 (42.0–62.6] and Control group [18.7 (16.0–24.7)] (p< 0.05). CONCLUSIONS: Non-asthmatic patients with intraoperative bronchospasm detected during anesthesia and endotracheal intubation showed increased expired nitric oxide. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2009-01 /pmc/articles/PMC2671975/ /pubmed/19142544 http://dx.doi.org/10.1590/S1807-59322009000100002 Text en Copyright © 2009 Hospital das Clínicas da FMUSP |
spellingShingle | Clinical Science Saraiva-Romanholo, Beatriz M. Machado, Fabio S. Almeida, Francine M. Nunes, Maria do Patrocínio T. Martins, Milton A. Vieira, Joaquim E. Non-Asthmatic Patients Show Increased Exhaled Nitric Oxide Concentrations |
title | Non-Asthmatic Patients Show Increased Exhaled Nitric Oxide
Concentrations |
title_full | Non-Asthmatic Patients Show Increased Exhaled Nitric Oxide
Concentrations |
title_fullStr | Non-Asthmatic Patients Show Increased Exhaled Nitric Oxide
Concentrations |
title_full_unstemmed | Non-Asthmatic Patients Show Increased Exhaled Nitric Oxide
Concentrations |
title_short | Non-Asthmatic Patients Show Increased Exhaled Nitric Oxide
Concentrations |
title_sort | non-asthmatic patients show increased exhaled nitric oxide
concentrations |
topic | Clinical Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671975/ https://www.ncbi.nlm.nih.gov/pubmed/19142544 http://dx.doi.org/10.1590/S1807-59322009000100002 |
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