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The Contribution of the Elastic Reaction is Severely Underestimated in Studies on Myofibril Contraction
We have considered the Huxley-Simmons manoeuvre. On the assumption that the quick release is an elastic process and on the basis of the isometric tension and of the stiffness of the muscle fibre we calculated that the spontaneous release of the fibre requires ∼43 μs, which is much faster than the ob...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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Molecular Diversity Preservation International (MDPI)
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672011/ https://www.ncbi.nlm.nih.gov/pubmed/19399230 |
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author | Grazi, Enrico Pozzati, Sara |
author_facet | Grazi, Enrico Pozzati, Sara |
author_sort | Grazi, Enrico |
collection | PubMed |
description | We have considered the Huxley-Simmons manoeuvre. On the assumption that the quick release is an elastic process and on the basis of the isometric tension and of the stiffness of the muscle fibre we calculated that the spontaneous release of the fibre requires ∼43 μs, which is much faster than the observed release, ∼180 μs. We concluded that the observed quick release is a guided process. After proper selection of the mass and of the stiffness of the system we mimicked the early recovery and noticed that most of the energy required to accomplish the early recovery is supplied by the kinetic energy accumulated during the course of the quick release. We computed that the frequency of the working strokes in the half sarcomere was between 4×10(6) and 40×10(6) s(−1). This is not to say that the ATPase rate constants are accumulative but only that the overall frequency of the working strokes in the half saromere is many orders of magnitude faster than the average ATPase rate constant. With this frequency no part of the Huxley-Simmons manoeuvre, quick release included, escapes the control of the working stroke. This means also that there is no reason to take the early recovery as an indication of the length of the working stroke. |
format | Text |
id | pubmed-2672011 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-26720112009-04-27 The Contribution of the Elastic Reaction is Severely Underestimated in Studies on Myofibril Contraction Grazi, Enrico Pozzati, Sara Int J Mol Sci Article We have considered the Huxley-Simmons manoeuvre. On the assumption that the quick release is an elastic process and on the basis of the isometric tension and of the stiffness of the muscle fibre we calculated that the spontaneous release of the fibre requires ∼43 μs, which is much faster than the observed release, ∼180 μs. We concluded that the observed quick release is a guided process. After proper selection of the mass and of the stiffness of the system we mimicked the early recovery and noticed that most of the energy required to accomplish the early recovery is supplied by the kinetic energy accumulated during the course of the quick release. We computed that the frequency of the working strokes in the half sarcomere was between 4×10(6) and 40×10(6) s(−1). This is not to say that the ATPase rate constants are accumulative but only that the overall frequency of the working strokes in the half saromere is many orders of magnitude faster than the average ATPase rate constant. With this frequency no part of the Huxley-Simmons manoeuvre, quick release included, escapes the control of the working stroke. This means also that there is no reason to take the early recovery as an indication of the length of the working stroke. Molecular Diversity Preservation International (MDPI) 2009-03-02 /pmc/articles/PMC2672011/ /pubmed/19399230 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Grazi, Enrico Pozzati, Sara The Contribution of the Elastic Reaction is Severely Underestimated in Studies on Myofibril Contraction |
title | The Contribution of the Elastic Reaction is Severely Underestimated in Studies on Myofibril Contraction |
title_full | The Contribution of the Elastic Reaction is Severely Underestimated in Studies on Myofibril Contraction |
title_fullStr | The Contribution of the Elastic Reaction is Severely Underestimated in Studies on Myofibril Contraction |
title_full_unstemmed | The Contribution of the Elastic Reaction is Severely Underestimated in Studies on Myofibril Contraction |
title_short | The Contribution of the Elastic Reaction is Severely Underestimated in Studies on Myofibril Contraction |
title_sort | contribution of the elastic reaction is severely underestimated in studies on myofibril contraction |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672011/ https://www.ncbi.nlm.nih.gov/pubmed/19399230 |
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