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The Contribution of the Elastic Reaction is Severely Underestimated in Studies on Myofibril Contraction

We have considered the Huxley-Simmons manoeuvre. On the assumption that the quick release is an elastic process and on the basis of the isometric tension and of the stiffness of the muscle fibre we calculated that the spontaneous release of the fibre requires ∼43 μs, which is much faster than the ob...

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Autores principales: Grazi, Enrico, Pozzati, Sara
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672011/
https://www.ncbi.nlm.nih.gov/pubmed/19399230
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author Grazi, Enrico
Pozzati, Sara
author_facet Grazi, Enrico
Pozzati, Sara
author_sort Grazi, Enrico
collection PubMed
description We have considered the Huxley-Simmons manoeuvre. On the assumption that the quick release is an elastic process and on the basis of the isometric tension and of the stiffness of the muscle fibre we calculated that the spontaneous release of the fibre requires ∼43 μs, which is much faster than the observed release, ∼180 μs. We concluded that the observed quick release is a guided process. After proper selection of the mass and of the stiffness of the system we mimicked the early recovery and noticed that most of the energy required to accomplish the early recovery is supplied by the kinetic energy accumulated during the course of the quick release. We computed that the frequency of the working strokes in the half sarcomere was between 4×10(6) and 40×10(6) s(−1). This is not to say that the ATPase rate constants are accumulative but only that the overall frequency of the working strokes in the half saromere is many orders of magnitude faster than the average ATPase rate constant. With this frequency no part of the Huxley-Simmons manoeuvre, quick release included, escapes the control of the working stroke. This means also that there is no reason to take the early recovery as an indication of the length of the working stroke.
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spelling pubmed-26720112009-04-27 The Contribution of the Elastic Reaction is Severely Underestimated in Studies on Myofibril Contraction Grazi, Enrico Pozzati, Sara Int J Mol Sci Article We have considered the Huxley-Simmons manoeuvre. On the assumption that the quick release is an elastic process and on the basis of the isometric tension and of the stiffness of the muscle fibre we calculated that the spontaneous release of the fibre requires ∼43 μs, which is much faster than the observed release, ∼180 μs. We concluded that the observed quick release is a guided process. After proper selection of the mass and of the stiffness of the system we mimicked the early recovery and noticed that most of the energy required to accomplish the early recovery is supplied by the kinetic energy accumulated during the course of the quick release. We computed that the frequency of the working strokes in the half sarcomere was between 4×10(6) and 40×10(6) s(−1). This is not to say that the ATPase rate constants are accumulative but only that the overall frequency of the working strokes in the half saromere is many orders of magnitude faster than the average ATPase rate constant. With this frequency no part of the Huxley-Simmons manoeuvre, quick release included, escapes the control of the working stroke. This means also that there is no reason to take the early recovery as an indication of the length of the working stroke. Molecular Diversity Preservation International (MDPI) 2009-03-02 /pmc/articles/PMC2672011/ /pubmed/19399230 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Grazi, Enrico
Pozzati, Sara
The Contribution of the Elastic Reaction is Severely Underestimated in Studies on Myofibril Contraction
title The Contribution of the Elastic Reaction is Severely Underestimated in Studies on Myofibril Contraction
title_full The Contribution of the Elastic Reaction is Severely Underestimated in Studies on Myofibril Contraction
title_fullStr The Contribution of the Elastic Reaction is Severely Underestimated in Studies on Myofibril Contraction
title_full_unstemmed The Contribution of the Elastic Reaction is Severely Underestimated in Studies on Myofibril Contraction
title_short The Contribution of the Elastic Reaction is Severely Underestimated in Studies on Myofibril Contraction
title_sort contribution of the elastic reaction is severely underestimated in studies on myofibril contraction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672011/
https://www.ncbi.nlm.nih.gov/pubmed/19399230
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