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Participation of Low Molecular Weight Electron Carriers in Oxidative Protein Folding
Oxidative protein folding is mediated by a proteinaceous electron relay system, in which the concerted action of protein disulfide isomerase and Ero1 delivers the electrons from thiol groups to the final acceptor. Oxygen appears to be the final oxidant in aerobic living organisms, although the exist...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Molecular Diversity Preservation International (MDPI)
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672033/ https://www.ncbi.nlm.nih.gov/pubmed/19399252 http://dx.doi.org/10.3390/ijms10031346 |
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author | Margittai, Éva Csala, Miklós Mandl, József Bánhegyi, Gábor |
author_facet | Margittai, Éva Csala, Miklós Mandl, József Bánhegyi, Gábor |
author_sort | Margittai, Éva |
collection | PubMed |
description | Oxidative protein folding is mediated by a proteinaceous electron relay system, in which the concerted action of protein disulfide isomerase and Ero1 delivers the electrons from thiol groups to the final acceptor. Oxygen appears to be the final oxidant in aerobic living organisms, although the existence of alternative electron acceptors, e.g. fumarate or nitrate, cannot be excluded. Whilst the protein components of the system are well-known, less attention has been turned to the role of low molecular weight electron carriers in the process. The function of ascorbate, tocopherol and vitamin K has been raised recently. In vitro and in vivo evidence suggests that these redox-active compounds can contribute to the functioning of oxidative folding. This review focuses on the participation of small molecular weight redox compounds in oxidative protein folding. |
format | Text |
id | pubmed-2672033 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-26720332009-04-27 Participation of Low Molecular Weight Electron Carriers in Oxidative Protein Folding Margittai, Éva Csala, Miklós Mandl, József Bánhegyi, Gábor Int J Mol Sci Review Oxidative protein folding is mediated by a proteinaceous electron relay system, in which the concerted action of protein disulfide isomerase and Ero1 delivers the electrons from thiol groups to the final acceptor. Oxygen appears to be the final oxidant in aerobic living organisms, although the existence of alternative electron acceptors, e.g. fumarate or nitrate, cannot be excluded. Whilst the protein components of the system are well-known, less attention has been turned to the role of low molecular weight electron carriers in the process. The function of ascorbate, tocopherol and vitamin K has been raised recently. In vitro and in vivo evidence suggests that these redox-active compounds can contribute to the functioning of oxidative folding. This review focuses on the participation of small molecular weight redox compounds in oxidative protein folding. Molecular Diversity Preservation International (MDPI) 2009-03-20 /pmc/articles/PMC2672033/ /pubmed/19399252 http://dx.doi.org/10.3390/ijms10031346 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Margittai, Éva Csala, Miklós Mandl, József Bánhegyi, Gábor Participation of Low Molecular Weight Electron Carriers in Oxidative Protein Folding |
title | Participation of Low Molecular Weight Electron Carriers in Oxidative Protein Folding |
title_full | Participation of Low Molecular Weight Electron Carriers in Oxidative Protein Folding |
title_fullStr | Participation of Low Molecular Weight Electron Carriers in Oxidative Protein Folding |
title_full_unstemmed | Participation of Low Molecular Weight Electron Carriers in Oxidative Protein Folding |
title_short | Participation of Low Molecular Weight Electron Carriers in Oxidative Protein Folding |
title_sort | participation of low molecular weight electron carriers in oxidative protein folding |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672033/ https://www.ncbi.nlm.nih.gov/pubmed/19399252 http://dx.doi.org/10.3390/ijms10031346 |
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