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Modifications of T-Scores by Quantitative Ultrasonography for the Diagnosis of Osteoporosis in Koreans

To identify a proper T-score threshold for the diagnosis of osteoporosis in Koreans using quantitative ultrasonography (QUS), normative data from 240 females and 238 males (ages 20-29 yr) were newly generated. Then, the osteoporosis prevalence estimate for men and women over 50 yr of age was analyze...

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Autores principales: Rhee, Yumie, Lee, Junho, Jung, Ji Young, Lee, Jung Eun, Park, So Young, Kim, Yoo Mee, Lee, Sihoon, Choi, Han Seok, Kim, Se Hwa, Lim, Sung-Kil
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672121/
https://www.ncbi.nlm.nih.gov/pubmed/19399263
http://dx.doi.org/10.3346/jkms.2009.24.2.232
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author Rhee, Yumie
Lee, Junho
Jung, Ji Young
Lee, Jung Eun
Park, So Young
Kim, Yoo Mee
Lee, Sihoon
Choi, Han Seok
Kim, Se Hwa
Lim, Sung-Kil
author_facet Rhee, Yumie
Lee, Junho
Jung, Ji Young
Lee, Jung Eun
Park, So Young
Kim, Yoo Mee
Lee, Sihoon
Choi, Han Seok
Kim, Se Hwa
Lim, Sung-Kil
author_sort Rhee, Yumie
collection PubMed
description To identify a proper T-score threshold for the diagnosis of osteoporosis in Koreans using quantitative ultrasonography (QUS), normative data from 240 females and 238 males (ages 20-29 yr) were newly generated. Then, the osteoporosis prevalence estimate for men and women over 50 yr of age was analyzed using previous World Health Organization (WHO) methods and heel QUS. T-scores were calculated from the normative data. There were definite negative correlations between age and all of the QUS parameters, such as speed of sound (SOS), broadband ultrasound attenuation (BUA), and estimated heel bone mineral density (BMD) (p<0.0001). After applying the recently determined prevalence of incident vertebral fracture in Koreans over 50 yr of age (11.6% and 9.1%, female vs male, respectively) to the diagnosis of osteoporosis by T-scores from heel BMD as measured by QUS, it was revealed that applicable T-scores for women and men were -2.25 and -1.85, respectively. These data suggest that simply using a T-score of -2.5, the classical WHO threshold for osteoporosis, underestimates the true prevalence when using peripheral QUS. Further prospective study of the power of QUS in predicting the absolute risk of fracture is needed.
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spelling pubmed-26721212009-04-27 Modifications of T-Scores by Quantitative Ultrasonography for the Diagnosis of Osteoporosis in Koreans Rhee, Yumie Lee, Junho Jung, Ji Young Lee, Jung Eun Park, So Young Kim, Yoo Mee Lee, Sihoon Choi, Han Seok Kim, Se Hwa Lim, Sung-Kil J Korean Med Sci Original Article To identify a proper T-score threshold for the diagnosis of osteoporosis in Koreans using quantitative ultrasonography (QUS), normative data from 240 females and 238 males (ages 20-29 yr) were newly generated. Then, the osteoporosis prevalence estimate for men and women over 50 yr of age was analyzed using previous World Health Organization (WHO) methods and heel QUS. T-scores were calculated from the normative data. There were definite negative correlations between age and all of the QUS parameters, such as speed of sound (SOS), broadband ultrasound attenuation (BUA), and estimated heel bone mineral density (BMD) (p<0.0001). After applying the recently determined prevalence of incident vertebral fracture in Koreans over 50 yr of age (11.6% and 9.1%, female vs male, respectively) to the diagnosis of osteoporosis by T-scores from heel BMD as measured by QUS, it was revealed that applicable T-scores for women and men were -2.25 and -1.85, respectively. These data suggest that simply using a T-score of -2.5, the classical WHO threshold for osteoporosis, underestimates the true prevalence when using peripheral QUS. Further prospective study of the power of QUS in predicting the absolute risk of fracture is needed. The Korean Academy of Medical Sciences 2009-04 2009-04-20 /pmc/articles/PMC2672121/ /pubmed/19399263 http://dx.doi.org/10.3346/jkms.2009.24.2.232 Text en Copyright © 2009 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Rhee, Yumie
Lee, Junho
Jung, Ji Young
Lee, Jung Eun
Park, So Young
Kim, Yoo Mee
Lee, Sihoon
Choi, Han Seok
Kim, Se Hwa
Lim, Sung-Kil
Modifications of T-Scores by Quantitative Ultrasonography for the Diagnosis of Osteoporosis in Koreans
title Modifications of T-Scores by Quantitative Ultrasonography for the Diagnosis of Osteoporosis in Koreans
title_full Modifications of T-Scores by Quantitative Ultrasonography for the Diagnosis of Osteoporosis in Koreans
title_fullStr Modifications of T-Scores by Quantitative Ultrasonography for the Diagnosis of Osteoporosis in Koreans
title_full_unstemmed Modifications of T-Scores by Quantitative Ultrasonography for the Diagnosis of Osteoporosis in Koreans
title_short Modifications of T-Scores by Quantitative Ultrasonography for the Diagnosis of Osteoporosis in Koreans
title_sort modifications of t-scores by quantitative ultrasonography for the diagnosis of osteoporosis in koreans
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672121/
https://www.ncbi.nlm.nih.gov/pubmed/19399263
http://dx.doi.org/10.3346/jkms.2009.24.2.232
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