Fatal Metformin Overdose Presenting with Progressive Hyperglycemia

A 29-year-old man with no history of diabetes ingested over 60 grams of metformin in a suicide attempt. He presented to the emergency department with acute renal insufficiency, severe lactic acidosis, and rapidly-progressive hyperglycemia. The patient’s peak serum glucose level of 707 mg/dL is the h...

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Detalles Bibliográficos
Autores principales: Suchard, Jeffrey R., Grotsky, Thomas A.
Formato: Texto
Lenguaje:English
Publicado: Department of Emergency Medicine, University of California, Irvine School of Medicine 2008
Materias:
Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672258/
https://www.ncbi.nlm.nih.gov/pubmed/19561734
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author Suchard, Jeffrey R.
Grotsky, Thomas A.
author_facet Suchard, Jeffrey R.
Grotsky, Thomas A.
author_sort Suchard, Jeffrey R.
collection PubMed
description A 29-year-old man with no history of diabetes ingested over 60 grams of metformin in a suicide attempt. He presented to the emergency department with acute renal insufficiency, severe lactic acidosis, and rapidly-progressive hyperglycemia. The patient’s peak serum glucose level of 707 mg/dL is the highest yet reported in a case of metformin toxicity. Treatment included sodium bicarbonate infusion and hemodialysis, but the patient suffered several cardiac arrests with pulseless electrical activity and ultimately expired 25 hours after the ingestion.
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spelling pubmed-26722582009-06-24 Fatal Metformin Overdose Presenting with Progressive Hyperglycemia Suchard, Jeffrey R. Grotsky, Thomas A. West J Emerg Med Toxicology A 29-year-old man with no history of diabetes ingested over 60 grams of metformin in a suicide attempt. He presented to the emergency department with acute renal insufficiency, severe lactic acidosis, and rapidly-progressive hyperglycemia. The patient’s peak serum glucose level of 707 mg/dL is the highest yet reported in a case of metformin toxicity. Treatment included sodium bicarbonate infusion and hemodialysis, but the patient suffered several cardiac arrests with pulseless electrical activity and ultimately expired 25 hours after the ingestion. Department of Emergency Medicine, University of California, Irvine School of Medicine 2008-08 /pmc/articles/PMC2672258/ /pubmed/19561734 Text en Copyright © 2008 the authors. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) License. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Toxicology
Suchard, Jeffrey R.
Grotsky, Thomas A.
Fatal Metformin Overdose Presenting with Progressive Hyperglycemia
title Fatal Metformin Overdose Presenting with Progressive Hyperglycemia
title_full Fatal Metformin Overdose Presenting with Progressive Hyperglycemia
title_fullStr Fatal Metformin Overdose Presenting with Progressive Hyperglycemia
title_full_unstemmed Fatal Metformin Overdose Presenting with Progressive Hyperglycemia
title_short Fatal Metformin Overdose Presenting with Progressive Hyperglycemia
title_sort fatal metformin overdose presenting with progressive hyperglycemia
topic Toxicology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672258/
https://www.ncbi.nlm.nih.gov/pubmed/19561734
work_keys_str_mv AT suchardjeffreyr fatalmetforminoverdosepresentingwithprogressivehyperglycemia
AT grotskythomasa fatalmetforminoverdosepresentingwithprogressivehyperglycemia

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