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Vitamin D Status of Clinical Practice Populations at Higher Latitudes: Analysis and Applications

BACKGROUND: Inadequate levels of vitamin D (VTD) throughout the life cycle from the fetal stage to adulthood have been correlated with elevated risk for assorted health afflictions. The purpose of this study was to ascertain VTD status and associated determinants in three clinical practice populatio...

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Autores principales: Genuis, Stephen J., Schwalfenberg, Gerry K., Hiltz, Michelle N., Vaselenak, Sharon A.
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672339/
https://www.ncbi.nlm.nih.gov/pubmed/19440275
http://dx.doi.org/10.3390/ijerph6010151
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author Genuis, Stephen J.
Schwalfenberg, Gerry K.
Hiltz, Michelle N.
Vaselenak, Sharon A.
author_facet Genuis, Stephen J.
Schwalfenberg, Gerry K.
Hiltz, Michelle N.
Vaselenak, Sharon A.
author_sort Genuis, Stephen J.
collection PubMed
description BACKGROUND: Inadequate levels of vitamin D (VTD) throughout the life cycle from the fetal stage to adulthood have been correlated with elevated risk for assorted health afflictions. The purpose of this study was to ascertain VTD status and associated determinants in three clinical practice populations living in Edmonton, Alberta, Canada - a locale with latitude of 53°30’N, where sun exposure from October through March is often inadequate to generate sufficient vitamin D. METHODS: To determine VTD status, 1,433 patients from three independent medical offices in Edmonton had levels drawn for 25(OH)D as part of their medical assessment between Jun 2001 and Mar 2007. The relationship between demographic data and lifestyle parameters with VTD status was explored. 25(OH)D levels were categorized as follows: (1) Deficient: <40 nmol/L; (2) Insufficient (moderate to mild): 40 to <80 nmol/L; and (3) Adequate: 80–250 nmol/L. Any cases <25 nmol/L were subcategorized as severely deficient for purposes of further analysis. RESULTS: 240 (16.75% of the total sample) of 1,433 patients were found to be VTD ‘deficient’ of which 48 (3.35% of the overall sample) had levels consistent with severe deficiency. 738 (51.5% of the overall sample) had ‘insufficiency’ (moderate to mild) while only 31.75% had ‘adequate’ 25(OH)D levels. The overall mean for 25(OH) D was 68.3 with SD=28.95. VTD status was significantly linked with demographic and lifestyle parameters including skin tone, fish consumption, milk intake, sun exposure, tanning bed use and nutritional supplementation. CONCLUSION: A high prevalence of hypovitaminosis-D was found in three clinical practice populations living in Edmonton. In view of the potential health sequelae associated with widespread VTD inadequacy, strategies to facilitate translation of emerging epidemiological information into clinical intervention need to be considered in order to address this public health issue. A suggested VTD supplemental intake level is presented for consideration.
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spelling pubmed-26723392009-05-13 Vitamin D Status of Clinical Practice Populations at Higher Latitudes: Analysis and Applications Genuis, Stephen J. Schwalfenberg, Gerry K. Hiltz, Michelle N. Vaselenak, Sharon A. Int J Environ Res Public Health Article BACKGROUND: Inadequate levels of vitamin D (VTD) throughout the life cycle from the fetal stage to adulthood have been correlated with elevated risk for assorted health afflictions. The purpose of this study was to ascertain VTD status and associated determinants in three clinical practice populations living in Edmonton, Alberta, Canada - a locale with latitude of 53°30’N, where sun exposure from October through March is often inadequate to generate sufficient vitamin D. METHODS: To determine VTD status, 1,433 patients from three independent medical offices in Edmonton had levels drawn for 25(OH)D as part of their medical assessment between Jun 2001 and Mar 2007. The relationship between demographic data and lifestyle parameters with VTD status was explored. 25(OH)D levels were categorized as follows: (1) Deficient: <40 nmol/L; (2) Insufficient (moderate to mild): 40 to <80 nmol/L; and (3) Adequate: 80–250 nmol/L. Any cases <25 nmol/L were subcategorized as severely deficient for purposes of further analysis. RESULTS: 240 (16.75% of the total sample) of 1,433 patients were found to be VTD ‘deficient’ of which 48 (3.35% of the overall sample) had levels consistent with severe deficiency. 738 (51.5% of the overall sample) had ‘insufficiency’ (moderate to mild) while only 31.75% had ‘adequate’ 25(OH)D levels. The overall mean for 25(OH) D was 68.3 with SD=28.95. VTD status was significantly linked with demographic and lifestyle parameters including skin tone, fish consumption, milk intake, sun exposure, tanning bed use and nutritional supplementation. CONCLUSION: A high prevalence of hypovitaminosis-D was found in three clinical practice populations living in Edmonton. In view of the potential health sequelae associated with widespread VTD inadequacy, strategies to facilitate translation of emerging epidemiological information into clinical intervention need to be considered in order to address this public health issue. A suggested VTD supplemental intake level is presented for consideration. Molecular Diversity Preservation International (MDPI) 2009-01 2009-01-07 /pmc/articles/PMC2672339/ /pubmed/19440275 http://dx.doi.org/10.3390/ijerph6010151 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
spellingShingle Article
Genuis, Stephen J.
Schwalfenberg, Gerry K.
Hiltz, Michelle N.
Vaselenak, Sharon A.
Vitamin D Status of Clinical Practice Populations at Higher Latitudes: Analysis and Applications
title Vitamin D Status of Clinical Practice Populations at Higher Latitudes: Analysis and Applications
title_full Vitamin D Status of Clinical Practice Populations at Higher Latitudes: Analysis and Applications
title_fullStr Vitamin D Status of Clinical Practice Populations at Higher Latitudes: Analysis and Applications
title_full_unstemmed Vitamin D Status of Clinical Practice Populations at Higher Latitudes: Analysis and Applications
title_short Vitamin D Status of Clinical Practice Populations at Higher Latitudes: Analysis and Applications
title_sort vitamin d status of clinical practice populations at higher latitudes: analysis and applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672339/
https://www.ncbi.nlm.nih.gov/pubmed/19440275
http://dx.doi.org/10.3390/ijerph6010151
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