Association between a Polymorphism of Aminolevulinate Dehydrogenase (ALAD) Gene and Blood Lead Levels in Japanese Subjects

This cross-sectional study investigated the relationship between the aminolevulinate dehydrogenase (ALAD) genotype and blood lead levels among 101 Japanese workers. Blood lead concentration measurement, biomarkers, and genotyping were performed. The minor allele frequency (MAF) for ALAD (ALAD2) was...

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Autores principales: Miyaki, Koichi, Lwin, Htay, Masaki, Katsunori, Song, Yixuan, Takahashi, Yoshimitsu, Muramatsu, Masaaki, Nakayama, Takeo
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672380/
https://www.ncbi.nlm.nih.gov/pubmed/19440429
http://dx.doi.org/10.3390/ijerph6030999
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author Miyaki, Koichi
Lwin, Htay
Masaki, Katsunori
Song, Yixuan
Takahashi, Yoshimitsu
Muramatsu, Masaaki
Nakayama, Takeo
author_facet Miyaki, Koichi
Lwin, Htay
Masaki, Katsunori
Song, Yixuan
Takahashi, Yoshimitsu
Muramatsu, Masaaki
Nakayama, Takeo
author_sort Miyaki, Koichi
collection PubMed
description This cross-sectional study investigated the relationship between the aminolevulinate dehydrogenase (ALAD) genotype and blood lead levels among 101 Japanese workers. Blood lead concentration measurement, biomarkers, and genotyping were performed. The minor allele frequency (MAF) for ALAD (ALAD2) was 0.08. Although the blood lead level in the subjects with heterozygous GC genotype was significantly higher than those with homozygous GG genotype, there were no significant differences for hemoglobin, hematocrit, serum and urinary ALA levels among genotypes. ALAD2 genotype was significantly associated with the blood lead concentration, even in the environmental lead exposed subjects. Further confirmation with a large sample size is needed.
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spelling pubmed-26723802009-05-13 Association between a Polymorphism of Aminolevulinate Dehydrogenase (ALAD) Gene and Blood Lead Levels in Japanese Subjects Miyaki, Koichi Lwin, Htay Masaki, Katsunori Song, Yixuan Takahashi, Yoshimitsu Muramatsu, Masaaki Nakayama, Takeo Int J Environ Res Public Health Article This cross-sectional study investigated the relationship between the aminolevulinate dehydrogenase (ALAD) genotype and blood lead levels among 101 Japanese workers. Blood lead concentration measurement, biomarkers, and genotyping were performed. The minor allele frequency (MAF) for ALAD (ALAD2) was 0.08. Although the blood lead level in the subjects with heterozygous GC genotype was significantly higher than those with homozygous GG genotype, there were no significant differences for hemoglobin, hematocrit, serum and urinary ALA levels among genotypes. ALAD2 genotype was significantly associated with the blood lead concentration, even in the environmental lead exposed subjects. Further confirmation with a large sample size is needed. Molecular Diversity Preservation International (MDPI) 2009-03 2009-03-06 /pmc/articles/PMC2672380/ /pubmed/19440429 http://dx.doi.org/10.3390/ijerph6030999 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Miyaki, Koichi
Lwin, Htay
Masaki, Katsunori
Song, Yixuan
Takahashi, Yoshimitsu
Muramatsu, Masaaki
Nakayama, Takeo
Association between a Polymorphism of Aminolevulinate Dehydrogenase (ALAD) Gene and Blood Lead Levels in Japanese Subjects
title Association between a Polymorphism of Aminolevulinate Dehydrogenase (ALAD) Gene and Blood Lead Levels in Japanese Subjects
title_full Association between a Polymorphism of Aminolevulinate Dehydrogenase (ALAD) Gene and Blood Lead Levels in Japanese Subjects
title_fullStr Association between a Polymorphism of Aminolevulinate Dehydrogenase (ALAD) Gene and Blood Lead Levels in Japanese Subjects
title_full_unstemmed Association between a Polymorphism of Aminolevulinate Dehydrogenase (ALAD) Gene and Blood Lead Levels in Japanese Subjects
title_short Association between a Polymorphism of Aminolevulinate Dehydrogenase (ALAD) Gene and Blood Lead Levels in Japanese Subjects
title_sort association between a polymorphism of aminolevulinate dehydrogenase (alad) gene and blood lead levels in japanese subjects
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672380/
https://www.ncbi.nlm.nih.gov/pubmed/19440429
http://dx.doi.org/10.3390/ijerph6030999
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