The actin regulator coronin-1A is mutated in a thymic egress deficient mouse strain and in a T(−)B(+)NK(+) SCID patient

Mice carrying the recessive peripheral T cell deficiency (Ptcd) locus have a block in thymic egress but the mechanism responsible is undefined. Here we found that Ptcd T cells have an intrinsic migration defect, impaired lymphoid tissue trafficking and irregularly shaped protrusions. Characterizatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Shiow, Lawrence R., Roadcap, David W., Paris, Kenneth, Watson, Susan R., Grigorova, Irina L., Lebet, Tonya, An, Jinping, Xu, Ying, Jenne, Craig N., Föger, Niko, Sorensen, Ricardo U., Goodnow, Christopher C., Bear, James E., Puck, Jennifer M., Cyster, Jason G.
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672406/
https://www.ncbi.nlm.nih.gov/pubmed/18836449
http://dx.doi.org/10.1038/ni.1662

Ejemplares similares

Ejemplares similares