CHK1 inhibition as a strategy for targeting fanconi anemia (FA) DNA repair pathway deficient tumors

BACKGROUND: DNA repair deficient tumor cells have been shown to accumulate high levels of DNA damage. Consequently, these cells become hyper-dependent on DNA damage response pathways, including the CHK1-kinase-mediated response. These observations suggest that DNA repair deficient tumors should exhi...

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Detalles Bibliográficos
Autores principales: Chen, Clark C, Kennedy, Richard D, Sidi, Samuel, Look, A Thomas, D'Andrea, Alan
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672921/
https://www.ncbi.nlm.nih.gov/pubmed/19371427
http://dx.doi.org/10.1186/1476-4598-8-24

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