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Controversies surrounding human papilloma virus infection, head & neck vs oral cancer, implications for prophylaxis and treatment

Head & Neck Cancer (HNC) represents the sixth most common malignancy worldwide and it is historically linked to well-known behavioural risk factors, i.e., tobacco smoking and/or the alcohol consumption. Recently, substantial evidence has been mounting that Human Papillomavirus (HPV) infection is...

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Autores principales: Campisi, Giuseppina, Giovannelli, Lucia
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673223/
https://www.ncbi.nlm.nih.gov/pubmed/19331691
http://dx.doi.org/10.1186/1758-3284-1-8
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author Campisi, Giuseppina
Giovannelli, Lucia
author_facet Campisi, Giuseppina
Giovannelli, Lucia
author_sort Campisi, Giuseppina
collection PubMed
description Head & Neck Cancer (HNC) represents the sixth most common malignancy worldwide and it is historically linked to well-known behavioural risk factors, i.e., tobacco smoking and/or the alcohol consumption. Recently, substantial evidence has been mounting that Human Papillomavirus (HPV) infection is playing an increasing important role in oral cancer. Because of the attention and clamor surrounding oral HPV infection and related cancers, as well as the use of HPV prophylactic vaccines, in this invited perspective the authors raise some questions and review some controversial issues on HPV infection and its role in HNC, with a particular focus on oral squamous cell carcinoma. The problematic definition and classification of HNC will be discussed, together with the characteristics of oral infection with oncogenic HPV types, the frequency of HPV DNA detection in HNC, the location of HPV-related tumours, the severity and prognosis of HPV-positive HNC, the diagnosis of oral HPV infection, common routes of oral infection and the likelihood of oro-genital HPV transmission, the prevention of HPV infection and novel therapeutic approaches.
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spelling pubmed-26732232009-04-25 Controversies surrounding human papilloma virus infection, head & neck vs oral cancer, implications for prophylaxis and treatment Campisi, Giuseppina Giovannelli, Lucia Head Neck Oncol Commentary Head & Neck Cancer (HNC) represents the sixth most common malignancy worldwide and it is historically linked to well-known behavioural risk factors, i.e., tobacco smoking and/or the alcohol consumption. Recently, substantial evidence has been mounting that Human Papillomavirus (HPV) infection is playing an increasing important role in oral cancer. Because of the attention and clamor surrounding oral HPV infection and related cancers, as well as the use of HPV prophylactic vaccines, in this invited perspective the authors raise some questions and review some controversial issues on HPV infection and its role in HNC, with a particular focus on oral squamous cell carcinoma. The problematic definition and classification of HNC will be discussed, together with the characteristics of oral infection with oncogenic HPV types, the frequency of HPV DNA detection in HNC, the location of HPV-related tumours, the severity and prognosis of HPV-positive HNC, the diagnosis of oral HPV infection, common routes of oral infection and the likelihood of oro-genital HPV transmission, the prevention of HPV infection and novel therapeutic approaches. BioMed Central 2009-03-30 /pmc/articles/PMC2673223/ /pubmed/19331691 http://dx.doi.org/10.1186/1758-3284-1-8 Text en Copyright © 2009 Campisi and Giovannelli; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Campisi, Giuseppina
Giovannelli, Lucia
Controversies surrounding human papilloma virus infection, head & neck vs oral cancer, implications for prophylaxis and treatment
title Controversies surrounding human papilloma virus infection, head & neck vs oral cancer, implications for prophylaxis and treatment
title_full Controversies surrounding human papilloma virus infection, head & neck vs oral cancer, implications for prophylaxis and treatment
title_fullStr Controversies surrounding human papilloma virus infection, head & neck vs oral cancer, implications for prophylaxis and treatment
title_full_unstemmed Controversies surrounding human papilloma virus infection, head & neck vs oral cancer, implications for prophylaxis and treatment
title_short Controversies surrounding human papilloma virus infection, head & neck vs oral cancer, implications for prophylaxis and treatment
title_sort controversies surrounding human papilloma virus infection, head & neck vs oral cancer, implications for prophylaxis and treatment
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673223/
https://www.ncbi.nlm.nih.gov/pubmed/19331691
http://dx.doi.org/10.1186/1758-3284-1-8
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