Prostate cancer stem cells

Despite the discovery over 60 years ago by Huggins and Hodges 1 that prostate cancers respond to androgen deprivation therapy, hormone-refractory prostate cancer remains a major clinical challenge. There is now mounting evidence that solid tumours originate from undifferentiated stem cell-like cells...

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Detalles Bibliográficos
Autores principales: Lang, SH, Frame, FM, Collins, AT
Formato: Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd. 2009
Materias:
Invited Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673349/
https://www.ncbi.nlm.nih.gov/pubmed/19040209
http://dx.doi.org/10.1002/path.2478
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author Lang, SH
Frame, FM
Collins, AT
author_facet Lang, SH
Frame, FM
Collins, AT
author_sort Lang, SH
collection PubMed
description Despite the discovery over 60 years ago by Huggins and Hodges 1 that prostate cancers respond to androgen deprivation therapy, hormone-refractory prostate cancer remains a major clinical challenge. There is now mounting evidence that solid tumours originate from undifferentiated stem cell-like cells coexisting within a heterogeneous tumour mass that drive tumour formation, maintain tumour homeostasis and initiate metastases. This review focuses upon current evidence for prostate cancer stem cells, addressing the identification and properties of both normal and transformed prostate stem cells.
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spelling pubmed-26733492009-05-15 Prostate cancer stem cells Lang, SH Frame, FM Collins, AT J Pathol Invited Review Despite the discovery over 60 years ago by Huggins and Hodges 1 that prostate cancers respond to androgen deprivation therapy, hormone-refractory prostate cancer remains a major clinical challenge. There is now mounting evidence that solid tumours originate from undifferentiated stem cell-like cells coexisting within a heterogeneous tumour mass that drive tumour formation, maintain tumour homeostasis and initiate metastases. This review focuses upon current evidence for prostate cancer stem cells, addressing the identification and properties of both normal and transformed prostate stem cells. John Wiley & Sons, Ltd. 2009-01 /pmc/articles/PMC2673349/ /pubmed/19040209 http://dx.doi.org/10.1002/path.2478 Text en Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
spellingShingle Invited Review
Lang, SH
Frame, FM
Collins, AT
Prostate cancer stem cells
title Prostate cancer stem cells
title_full Prostate cancer stem cells
title_fullStr Prostate cancer stem cells
title_full_unstemmed Prostate cancer stem cells
title_short Prostate cancer stem cells
title_sort prostate cancer stem cells
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673349/
https://www.ncbi.nlm.nih.gov/pubmed/19040209
http://dx.doi.org/10.1002/path.2478
work_keys_str_mv AT langsh prostatecancerstemcells
AT framefm prostatecancerstemcells
AT collinsat prostatecancerstemcells

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