RAD18 promotes DNA double-strand break repair during G1 phase through chromatin retention of 53BP1

Recruitment of RAD18 to stalled replication forks facilitates monoubiquitination of PCNA during S-phase, promoting translesion synthesis at sites of UV irradiation-induced DNA damage. In this study, we show that RAD18 is also recruited to ionizing radiation (IR)-induced sites of DNA double-strand br...

Descripción completa

Detalles Bibliográficos
Autores principales: Watanabe, Kenji, Iwabuchi, Kuniyoshi, Sun, Jinghua, Tsuji, Yuri, Tani, Tokio, Tokunaga, Kazuaki, Date, Takayasu, Hashimoto, Mitsumasa, Yamaizumi, Masaru, Tateishi, Satoshi
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673428/
https://www.ncbi.nlm.nih.gov/pubmed/19228710
http://dx.doi.org/10.1093/nar/gkp082

Ejemplares similares

Ejemplares similares