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Immunohistochemical Localization of the Bradykinin B1 and B2 Receptors in Human Nasal Mucosa

Bradykinin (BK) has been tobe thought a potent mediator involved in allergic rhinitis because BK was recovered from the nasal lavage fluid of allergic rhinitis patients after allergen provocation and BK receptor antagonists relief nasal allergic symptoms. Two mammalian BK receptor subtypes, B1 and B...

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Autores principales: Shirasaki, Hideaki, Kanaizumi, Etsuko, Himi, Tetsuo
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673475/
https://www.ncbi.nlm.nih.gov/pubmed/19404481
http://dx.doi.org/10.1155/2009/102406
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author Shirasaki, Hideaki
Kanaizumi, Etsuko
Himi, Tetsuo
author_facet Shirasaki, Hideaki
Kanaizumi, Etsuko
Himi, Tetsuo
author_sort Shirasaki, Hideaki
collection PubMed
description Bradykinin (BK) has been tobe thought a potent mediator involved in allergic rhinitis because BK was recovered from the nasal lavage fluid of allergic rhinitis patients after allergen provocation and BK receptor antagonists relief nasal allergic symptoms. Two mammalian BK receptor subtypes, B1 and B2, have been defined based on their pharmacological properties. We investigated the localization of these receptors by immunohistochemistry. Human turbinates were obtained after turbinectomy from 12 patients with nasal obstruction refractory to medical therapy. The immunohistochemical study revealed that epithelial cells, submucosal glands, fibroblast, vascular smooth muscle, vascular endothelial cells, and macrophages showed immunoreactivity for both B1 and B2 receptors. The B2 receptor expression was found in peripheral nerve fibers, whereas the B1 expression was not observed in nerves. The results may have an important clinical implication for understanding the differential roles of BK receptor subtypes on upper airway diseases such as allergic rhinitis and nonallergic rhinitis.
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spelling pubmed-26734752009-04-29 Immunohistochemical Localization of the Bradykinin B1 and B2 Receptors in Human Nasal Mucosa Shirasaki, Hideaki Kanaizumi, Etsuko Himi, Tetsuo Mediators Inflamm Clinical Study Bradykinin (BK) has been tobe thought a potent mediator involved in allergic rhinitis because BK was recovered from the nasal lavage fluid of allergic rhinitis patients after allergen provocation and BK receptor antagonists relief nasal allergic symptoms. Two mammalian BK receptor subtypes, B1 and B2, have been defined based on their pharmacological properties. We investigated the localization of these receptors by immunohistochemistry. Human turbinates were obtained after turbinectomy from 12 patients with nasal obstruction refractory to medical therapy. The immunohistochemical study revealed that epithelial cells, submucosal glands, fibroblast, vascular smooth muscle, vascular endothelial cells, and macrophages showed immunoreactivity for both B1 and B2 receptors. The B2 receptor expression was found in peripheral nerve fibers, whereas the B1 expression was not observed in nerves. The results may have an important clinical implication for understanding the differential roles of BK receptor subtypes on upper airway diseases such as allergic rhinitis and nonallergic rhinitis. Hindawi Publishing Corporation 2009 2009-04-23 /pmc/articles/PMC2673475/ /pubmed/19404481 http://dx.doi.org/10.1155/2009/102406 Text en Copyright © 2009 Hideaki Shirasaki et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Shirasaki, Hideaki
Kanaizumi, Etsuko
Himi, Tetsuo
Immunohistochemical Localization of the Bradykinin B1 and B2 Receptors in Human Nasal Mucosa
title Immunohistochemical Localization of the Bradykinin B1 and B2 Receptors in Human Nasal Mucosa
title_full Immunohistochemical Localization of the Bradykinin B1 and B2 Receptors in Human Nasal Mucosa
title_fullStr Immunohistochemical Localization of the Bradykinin B1 and B2 Receptors in Human Nasal Mucosa
title_full_unstemmed Immunohistochemical Localization of the Bradykinin B1 and B2 Receptors in Human Nasal Mucosa
title_short Immunohistochemical Localization of the Bradykinin B1 and B2 Receptors in Human Nasal Mucosa
title_sort immunohistochemical localization of the bradykinin b1 and b2 receptors in human nasal mucosa
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673475/
https://www.ncbi.nlm.nih.gov/pubmed/19404481
http://dx.doi.org/10.1155/2009/102406
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