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Gene expression and hepatitis C virus infection

Hepatitis C virus (HCV) is a major cause of chronic liver disease, with about 170 million people infected worldwide. Up to 70% of patients will have persistent infection after inoculation, making this disease a significant cause of morbidity and mortality. The severity of disease varies widely, from...

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Autores principales: Asselah, T, Bièche, I, Sabbagh, A, Bedossa, P, Moreau, R, Valla, D, Vidaud, M, Marcellin, P
Formato: Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673514/
https://www.ncbi.nlm.nih.gov/pubmed/19074178
http://dx.doi.org/10.1136/gut.2008.166348
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author Asselah, T
Bièche, I
Sabbagh, A
Bedossa, P
Moreau, R
Valla, D
Vidaud, M
Marcellin, P
author_facet Asselah, T
Bièche, I
Sabbagh, A
Bedossa, P
Moreau, R
Valla, D
Vidaud, M
Marcellin, P
author_sort Asselah, T
collection PubMed
description Hepatitis C virus (HCV) is a major cause of chronic liver disease, with about 170 million people infected worldwide. Up to 70% of patients will have persistent infection after inoculation, making this disease a significant cause of morbidity and mortality. The severity of disease varies widely, from asymptomatic chronic infection to cirrhosis and hepatocellular carcinoma. Since the discovery of HCV, the treatment of hepatitis C has considerably improved. Recently, combination of pegylated interferons with ribavirin gives a response rate of about 55%. Treatment is indicated in patients with moderate or severe fibrosis. The tolerability of combination treatment is relatively poor, with a frequent flu-like syndrome and an impaired quality of life. In addition to viral and environmental behavioural factors, host genetic diversity is believed to contribute to the spectrum of clinical outcomes in HCV infection. The sequencing of the human genome, together with the development of high-throughput technologies that measure the function of the genome, have afforded unique opportunities to develop profiles that can distinguish, identify and classify discrete subsets of disease, predict the disease outcome or predict the response to treatment. This paper reviews the published literature on gene expression associated with HCV infection (HCV infection, fibrosis progression), and also according to response to treatment.
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spelling pubmed-26735142009-04-27 Gene expression and hepatitis C virus infection Asselah, T Bièche, I Sabbagh, A Bedossa, P Moreau, R Valla, D Vidaud, M Marcellin, P Gut Recent Advances in Basic Science Hepatitis C virus (HCV) is a major cause of chronic liver disease, with about 170 million people infected worldwide. Up to 70% of patients will have persistent infection after inoculation, making this disease a significant cause of morbidity and mortality. The severity of disease varies widely, from asymptomatic chronic infection to cirrhosis and hepatocellular carcinoma. Since the discovery of HCV, the treatment of hepatitis C has considerably improved. Recently, combination of pegylated interferons with ribavirin gives a response rate of about 55%. Treatment is indicated in patients with moderate or severe fibrosis. The tolerability of combination treatment is relatively poor, with a frequent flu-like syndrome and an impaired quality of life. In addition to viral and environmental behavioural factors, host genetic diversity is believed to contribute to the spectrum of clinical outcomes in HCV infection. The sequencing of the human genome, together with the development of high-throughput technologies that measure the function of the genome, have afforded unique opportunities to develop profiles that can distinguish, identify and classify discrete subsets of disease, predict the disease outcome or predict the response to treatment. This paper reviews the published literature on gene expression associated with HCV infection (HCV infection, fibrosis progression), and also according to response to treatment. BMJ Publishing Group 2009-06 2008-12-10 /pmc/articles/PMC2673514/ /pubmed/19074178 http://dx.doi.org/10.1136/gut.2008.166348 Text en © Asselah et al 2009 http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Recent Advances in Basic Science
Asselah, T
Bièche, I
Sabbagh, A
Bedossa, P
Moreau, R
Valla, D
Vidaud, M
Marcellin, P
Gene expression and hepatitis C virus infection
title Gene expression and hepatitis C virus infection
title_full Gene expression and hepatitis C virus infection
title_fullStr Gene expression and hepatitis C virus infection
title_full_unstemmed Gene expression and hepatitis C virus infection
title_short Gene expression and hepatitis C virus infection
title_sort gene expression and hepatitis c virus infection
topic Recent Advances in Basic Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673514/
https://www.ncbi.nlm.nih.gov/pubmed/19074178
http://dx.doi.org/10.1136/gut.2008.166348
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