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Nanomedicines in the treatment of chronic hepatitis C – focus on pegylated interferon alpha-2a
Nanotechnology is the application of nanotechnology within medicine. An illustration of this is the use of pegylation as a means of modifying naturally occurring proteins which may have clinical applications, in order to improve the pharmacodynamics of the protein resulting in an effective medicatio...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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Dove Medical Press
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673816/ https://www.ncbi.nlm.nih.gov/pubmed/17722508 |
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author | Thomas, Thea Foster, Graham |
author_facet | Thomas, Thea Foster, Graham |
author_sort | Thomas, Thea |
collection | PubMed |
description | Nanotechnology is the application of nanotechnology within medicine. An illustration of this is the use of pegylation as a means of modifying naturally occurring proteins which may have clinical applications, in order to improve the pharmacodynamics of the protein resulting in an effective medication. An example of this is pegylated interferon. The purpose of this review is to examine the chemistry, clinical pharmacology, pharmacokinetics, pharmacodynamics, and clinical studies with 40 kDa pegylated interferon to illustrate the general principles of pegylated biological proteins. The use in clinical practice is reviewed along with the evidence for both efficiacy, safety, and advantages over standard interferon. |
format | Text |
id | pubmed-2673816 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-26738162009-04-30 Nanomedicines in the treatment of chronic hepatitis C – focus on pegylated interferon alpha-2a Thomas, Thea Foster, Graham Int J Nanomedicine Review Nanotechnology is the application of nanotechnology within medicine. An illustration of this is the use of pegylation as a means of modifying naturally occurring proteins which may have clinical applications, in order to improve the pharmacodynamics of the protein resulting in an effective medication. An example of this is pegylated interferon. The purpose of this review is to examine the chemistry, clinical pharmacology, pharmacokinetics, pharmacodynamics, and clinical studies with 40 kDa pegylated interferon to illustrate the general principles of pegylated biological proteins. The use in clinical practice is reviewed along with the evidence for both efficiacy, safety, and advantages over standard interferon. Dove Medical Press 2007-03 2007-03 /pmc/articles/PMC2673816/ /pubmed/17722508 Text en © 2007 Dove Medical Press Limited. All rights reserved |
spellingShingle | Review Thomas, Thea Foster, Graham Nanomedicines in the treatment of chronic hepatitis C – focus on pegylated interferon alpha-2a |
title | Nanomedicines in the treatment of chronic hepatitis C – focus on pegylated interferon alpha-2a |
title_full | Nanomedicines in the treatment of chronic hepatitis C – focus on pegylated interferon alpha-2a |
title_fullStr | Nanomedicines in the treatment of chronic hepatitis C – focus on pegylated interferon alpha-2a |
title_full_unstemmed | Nanomedicines in the treatment of chronic hepatitis C – focus on pegylated interferon alpha-2a |
title_short | Nanomedicines in the treatment of chronic hepatitis C – focus on pegylated interferon alpha-2a |
title_sort | nanomedicines in the treatment of chronic hepatitis c – focus on pegylated interferon alpha-2a |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673816/ https://www.ncbi.nlm.nih.gov/pubmed/17722508 |
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