Glutaric acid as a spacer facilitates improved intracellular uptake of LHRH–SPION into human breast cancer cells

Superparamagnetic iron oxide nanoparticles (SPIONs) bound directly to luteinizing hormone releasing hormone (LHRH) have shown high efficiency for intracellular uptake to breast cancer cells, MDA-MB-435S.luc. We demonstrate in this communication that inclusion of a small spacer molecule such as gluta...

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Detalles Bibliográficos
Autores principales: Kumar, Challa SSR, Leuschner, Carola, Urbina, Michelle, Ozkaya, Tevhida, Hormes, Josef
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2007
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673973/
https://www.ncbi.nlm.nih.gov/pubmed/17722545
Descripción
Sumario:Superparamagnetic iron oxide nanoparticles (SPIONs) bound directly to luteinizing hormone releasing hormone (LHRH) have shown high efficiency for intracellular uptake to breast cancer cells, MDA-MB-435S.luc. We demonstrate in this communication that inclusion of a small spacer molecule such as glutaric acid (Glu) in between SPION and LHRH increases further receptor mediated intracellular uptake. LHRH-bound SPIONs with and without the spacer molecule were nontoxic.

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