Glutaric acid as a spacer facilitates improved intracellular uptake of LHRH–SPION into human breast cancer cells

Superparamagnetic iron oxide nanoparticles (SPIONs) bound directly to luteinizing hormone releasing hormone (LHRH) have shown high efficiency for intracellular uptake to breast cancer cells, MDA-MB-435S.luc. We demonstrate in this communication that inclusion of a small spacer molecule such as gluta...

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Detalles Bibliográficos
Autores principales: Kumar, Challa SSR, Leuschner, Carola, Urbina, Michelle, Ozkaya, Tevhida, Hormes, Josef
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2007
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673973/
https://www.ncbi.nlm.nih.gov/pubmed/17722545
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author Kumar, Challa SSR
Leuschner, Carola
Urbina, Michelle
Ozkaya, Tevhida
Hormes, Josef
author_facet Kumar, Challa SSR
Leuschner, Carola
Urbina, Michelle
Ozkaya, Tevhida
Hormes, Josef
author_sort Kumar, Challa SSR
collection PubMed
description Superparamagnetic iron oxide nanoparticles (SPIONs) bound directly to luteinizing hormone releasing hormone (LHRH) have shown high efficiency for intracellular uptake to breast cancer cells, MDA-MB-435S.luc. We demonstrate in this communication that inclusion of a small spacer molecule such as glutaric acid (Glu) in between SPION and LHRH increases further receptor mediated intracellular uptake. LHRH-bound SPIONs with and without the spacer molecule were nontoxic.
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spelling pubmed-26739732009-04-30 Glutaric acid as a spacer facilitates improved intracellular uptake of LHRH–SPION into human breast cancer cells Kumar, Challa SSR Leuschner, Carola Urbina, Michelle Ozkaya, Tevhida Hormes, Josef Int J Nanomedicine Brief Communication Superparamagnetic iron oxide nanoparticles (SPIONs) bound directly to luteinizing hormone releasing hormone (LHRH) have shown high efficiency for intracellular uptake to breast cancer cells, MDA-MB-435S.luc. We demonstrate in this communication that inclusion of a small spacer molecule such as glutaric acid (Glu) in between SPION and LHRH increases further receptor mediated intracellular uptake. LHRH-bound SPIONs with and without the spacer molecule were nontoxic. Dove Medical Press 2007-06 2007-06 /pmc/articles/PMC2673973/ /pubmed/17722545 Text en © 2007 Dove Medical Press Limited. All rights reserved
spellingShingle Brief Communication
Kumar, Challa SSR
Leuschner, Carola
Urbina, Michelle
Ozkaya, Tevhida
Hormes, Josef
Glutaric acid as a spacer facilitates improved intracellular uptake of LHRH–SPION into human breast cancer cells
title Glutaric acid as a spacer facilitates improved intracellular uptake of LHRH–SPION into human breast cancer cells
title_full Glutaric acid as a spacer facilitates improved intracellular uptake of LHRH–SPION into human breast cancer cells
title_fullStr Glutaric acid as a spacer facilitates improved intracellular uptake of LHRH–SPION into human breast cancer cells
title_full_unstemmed Glutaric acid as a spacer facilitates improved intracellular uptake of LHRH–SPION into human breast cancer cells
title_short Glutaric acid as a spacer facilitates improved intracellular uptake of LHRH–SPION into human breast cancer cells
title_sort glutaric acid as a spacer facilitates improved intracellular uptake of lhrh–spion into human breast cancer cells
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673973/
https://www.ncbi.nlm.nih.gov/pubmed/17722545
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