Developmental Regulation of Hepatitis B Virus Biosynthesis by Hepatocyte Nuclear Factor 4α

The host cellular factors that promote persistent viral infections in vivo are, in general, poorly understood. Utilizing the hepatitis B virus (HBV) transgenic mouse model of chronic infection, we demonstrate that the nuclear receptor, hepatocyte nuclear factor 4α (HNF4α, NR2A1), is essential for vi...

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Autores principales: Li, Lie, Oropeza, Claudia E., Sainz, Bruno, Uprichard, Susan L., Gonzalez, Frank J., McLachlan, Alan
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674568/
https://www.ncbi.nlm.nih.gov/pubmed/19424486
http://dx.doi.org/10.1371/journal.pone.0005489
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author Li, Lie
Oropeza, Claudia E.
Sainz, Bruno
Uprichard, Susan L.
Gonzalez, Frank J.
McLachlan, Alan
author_facet Li, Lie
Oropeza, Claudia E.
Sainz, Bruno
Uprichard, Susan L.
Gonzalez, Frank J.
McLachlan, Alan
author_sort Li, Lie
collection PubMed
description The host cellular factors that promote persistent viral infections in vivo are, in general, poorly understood. Utilizing the hepatitis B virus (HBV) transgenic mouse model of chronic infection, we demonstrate that the nuclear receptor, hepatocyte nuclear factor 4α (HNF4α, NR2A1), is essential for viral biosynthesis in the liver. The dependency of HBV transcription on HNF4α links viral biosynthesis and persistence to a developmentally regulated transcription factor essential for host viability.
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spelling pubmed-26745682009-05-08 Developmental Regulation of Hepatitis B Virus Biosynthesis by Hepatocyte Nuclear Factor 4α Li, Lie Oropeza, Claudia E. Sainz, Bruno Uprichard, Susan L. Gonzalez, Frank J. McLachlan, Alan PLoS One Research Article The host cellular factors that promote persistent viral infections in vivo are, in general, poorly understood. Utilizing the hepatitis B virus (HBV) transgenic mouse model of chronic infection, we demonstrate that the nuclear receptor, hepatocyte nuclear factor 4α (HNF4α, NR2A1), is essential for viral biosynthesis in the liver. The dependency of HBV transcription on HNF4α links viral biosynthesis and persistence to a developmentally regulated transcription factor essential for host viability. Public Library of Science 2009-05-08 /pmc/articles/PMC2674568/ /pubmed/19424486 http://dx.doi.org/10.1371/journal.pone.0005489 Text en Li et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Li, Lie
Oropeza, Claudia E.
Sainz, Bruno
Uprichard, Susan L.
Gonzalez, Frank J.
McLachlan, Alan
Developmental Regulation of Hepatitis B Virus Biosynthesis by Hepatocyte Nuclear Factor 4α
title Developmental Regulation of Hepatitis B Virus Biosynthesis by Hepatocyte Nuclear Factor 4α
title_full Developmental Regulation of Hepatitis B Virus Biosynthesis by Hepatocyte Nuclear Factor 4α
title_fullStr Developmental Regulation of Hepatitis B Virus Biosynthesis by Hepatocyte Nuclear Factor 4α
title_full_unstemmed Developmental Regulation of Hepatitis B Virus Biosynthesis by Hepatocyte Nuclear Factor 4α
title_short Developmental Regulation of Hepatitis B Virus Biosynthesis by Hepatocyte Nuclear Factor 4α
title_sort developmental regulation of hepatitis b virus biosynthesis by hepatocyte nuclear factor 4α
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674568/
https://www.ncbi.nlm.nih.gov/pubmed/19424486
http://dx.doi.org/10.1371/journal.pone.0005489
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