Heritable Targeted Gene Disruption in Zebrafish Using Designed Zinc Finger Nucleases

We describe here the use of zinc finger nucleases (ZFNs) for somatic and germline disruption of genes in zebrafish (Danio rerio), where targeted mutagenesis was previously intractable. ZFNs induce a targeted double-strand break in the genome that is repaired to generate small insertions and deletion...

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Detalles Bibliográficos
Autores principales: Doyon, Yannick, McCammon, Jasmine M, Miller, Jeffrey C, Faraji, Farhoud, Ngo, Catherine, Katibah, George E, Amora, Rainier, Hocking, Toby D, Zhang, Lei, Rebar, Edward J, Gregory, Philip D, Urnov, Fyodor D, Amacher, Sharon L
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674762/
https://www.ncbi.nlm.nih.gov/pubmed/18500334
http://dx.doi.org/10.1038/nbt1409

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674762/
https://www.ncbi.nlm.nih.gov/pubmed/18500334
http://dx.doi.org/10.1038/nbt1409

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