Generation in vivo of peptide-specific cytotoxic T cells and presence of regulatory T cells during vaccination with hTERT (class I and II) peptide-pulsed DCs

BACKGROUND: Optimal techniques for DC generation for immunotherapy in cancer are yet to be established. Study aims were to evaluate: (i) DC activation/maturation milieu (TNF-α +/- IFN-α) and its effects on CD8+ hTERT-specific T cell responses to class I epitopes (p540 or p865), (ii) CD8+ hTERT-speci...

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Detalles Bibliográficos
Autores principales: Aloysius, Mark M, Mc Kechnie, Alastair J, Robins, Richard A, Verma, Chandan, Eremin, Jennifer M, Farzaneh, Farzin, Habib, Nagy A, Bhalla, Joti, Hardwick, Nicola R, Satthaporn, Sukchai, Sreenivasan, Thiagarajan, El-Sheemy, Mohammed, Eremin, Oleg
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674878/
https://www.ncbi.nlm.nih.gov/pubmed/19298672
http://dx.doi.org/10.1186/1479-5876-7-18

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