Involvment of Cytosolic and Mitochondrial GSK-3β in Mitochondrial Dysfunction and Neuronal Cell Death of MPTP/MPP(+)-Treated Neurons

Aberrant mitochondrial function appears to play a central role in dopaminergic neuronal loss in Parkinson's disease (PD). 1-methyl-4-phenylpyridinium iodide (MPP(+)), the active metabolite of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), is a selective inhibitor of mitochondrial complex...

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Detalles Bibliográficos
Autores principales: Petit-Paitel, Agnès, Brau, Frédéric, Cazareth, Julie, Chabry, Joëlle
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675062/
https://www.ncbi.nlm.nih.gov/pubmed/19430525
http://dx.doi.org/10.1371/journal.pone.0005491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675062/
https://www.ncbi.nlm.nih.gov/pubmed/19430525
http://dx.doi.org/10.1371/journal.pone.0005491

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