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A Toxicology for the 21st Century—Mapping the Road Ahead
The landmark publication by the National Research Council putting forward a vision of a toxicology for the 21st century in 2007 has created an atmosphere of departure in our field. The alliances formed, symposia and meetings held and the articles following are remarkable, indicating that this is an...
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Formato: | Texto |
Lenguaje: | English |
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Oxford University Press
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675641/ https://www.ncbi.nlm.nih.gov/pubmed/19357069 http://dx.doi.org/10.1093/toxsci/kfp059 |
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author | Hartung, Thomas |
author_facet | Hartung, Thomas |
author_sort | Hartung, Thomas |
collection | PubMed |
description | The landmark publication by the National Research Council putting forward a vision of a toxicology for the 21st century in 2007 has created an atmosphere of departure in our field. The alliances formed, symposia and meetings held and the articles following are remarkable, indicating that this is an idea whose time has come. Most of the discussion centers on the technical opportunities to map pathways of toxicity and the financing of the program. Here, the other part of the work ahead shall be discussed, that is, the focus is on regulatory implementation once the technological challenges are managed, but we are well aware that the technical aspects of what the National Academy of Science report suggests still need to be addressed: A series of challenges are put forward which we will face in addition to finding a technical solution (and its funding) to set this vision into practice. This includes the standardization and quality assurance of novel methodologies, their formal validation, their integration into test strategies including threshold setting and finally a global acceptance and implementation. This will require intense conceptual steering to have all pieces of the puzzle come together. |
format | Text |
id | pubmed-2675641 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-26756412009-05-05 A Toxicology for the 21st Century—Mapping the Road Ahead Hartung, Thomas Toxicol Sci Forum Series, Part III The landmark publication by the National Research Council putting forward a vision of a toxicology for the 21st century in 2007 has created an atmosphere of departure in our field. The alliances formed, symposia and meetings held and the articles following are remarkable, indicating that this is an idea whose time has come. Most of the discussion centers on the technical opportunities to map pathways of toxicity and the financing of the program. Here, the other part of the work ahead shall be discussed, that is, the focus is on regulatory implementation once the technological challenges are managed, but we are well aware that the technical aspects of what the National Academy of Science report suggests still need to be addressed: A series of challenges are put forward which we will face in addition to finding a technical solution (and its funding) to set this vision into practice. This includes the standardization and quality assurance of novel methodologies, their formal validation, their integration into test strategies including threshold setting and finally a global acceptance and implementation. This will require intense conceptual steering to have all pieces of the puzzle come together. Oxford University Press 2009-05 2009-04-08 /pmc/articles/PMC2675641/ /pubmed/19357069 http://dx.doi.org/10.1093/toxsci/kfp059 Text en © The Author 2009. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org. |
spellingShingle | Forum Series, Part III Hartung, Thomas A Toxicology for the 21st Century—Mapping the Road Ahead |
title | A Toxicology for the 21st Century—Mapping the Road Ahead |
title_full | A Toxicology for the 21st Century—Mapping the Road Ahead |
title_fullStr | A Toxicology for the 21st Century—Mapping the Road Ahead |
title_full_unstemmed | A Toxicology for the 21st Century—Mapping the Road Ahead |
title_short | A Toxicology for the 21st Century—Mapping the Road Ahead |
title_sort | toxicology for the 21st century—mapping the road ahead |
topic | Forum Series, Part III |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675641/ https://www.ncbi.nlm.nih.gov/pubmed/19357069 http://dx.doi.org/10.1093/toxsci/kfp059 |
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