The Roles of β-Tubulin Mutations and Isotype Expression in Acquired Drug Resistance

The antitumor drug paclitaxel stabilizes microtubules and reduces their dynamicity, promoting mitotic arrest and eventually apoptosis. Upon assembly of the α/β-tubulin heterodimer, GTP becomes bound to both the α and β-tubulin monomers. During microtubule assembly, the GTP bound to β-tubulin is hydr...

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Detalles Bibliográficos
Autores principales: Huzil, J. Torin, Chen, Ke, Kurgan, Lukasz, Tuszynski, Jack A.
Formato: Texto
Lenguaje:English
Publicado: Libertas Academica 2007
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675838/
https://www.ncbi.nlm.nih.gov/pubmed/19455242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675838/
https://www.ncbi.nlm.nih.gov/pubmed/19455242

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