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Nicastrin Is Dispensable for γ-Secretase Protease Activity in the Presence of Specific Presenilin Mutations

γ-Secretase is a multisubunit membrane protein complex consisting of presenilin (PS1), nicastrin (NCT), anterior pharynx-1, and presenilin enhancer 2. To analyze the activity of familial Alzheimer disease mutants and to understand the roles of the subunits, we established a yeast transcriptional act...

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Detalles Bibliográficos
Autores principales:	Futai, Eugene, Yagishita, Sosuke, Ishiura, Shoichi
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2009
Materias:	Enzyme Catalysis and Regulation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676034/ https://www.ncbi.nlm.nih.gov/pubmed/19254953 http://dx.doi.org/10.1074/jbc.M807653200

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