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Induction of p21(CIP1/WAF1 )expression by human T-lymphotropic virus type 1 Tax requires transcriptional activation and mRNA stabilization

HTLV-1 Tax can induce senescence by up-regulating the levels of cyclin-dependent kinase inhibitors p21(CIP1/WAF1 )and p27(KIP1). Tax increases p27(KIP1 )protein stability by activating the anaphase promoting complex/cyclosome (APC/C) precociously, causing degradation of Skp2 and inactivation of SCF(...

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Detalles Bibliográficos
Autores principales:	Zhang, Ling, Zhi, Huijun, Liu, Meihong, Kuo, Yu-Liang, Giam, Chou-Zen
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676247/ https://www.ncbi.nlm.nih.gov/pubmed/19356250 http://dx.doi.org/10.1186/1742-4690-6-35

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