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Serum markers in interstitial pneumonia with and without Pneumocystis jirovecii colonization: a prospective study

BACKGROUND: In patients with chronic respiratory disease, Pneumocystis jirovecii (P. jirovecii) colonization is observed, and may influence disease progression and systemic inflammation. Pneumocystis pneumonia causes interstitial changes, so making a diagnosis of PCP in patients who have interstitia...

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Autores principales: Shimizu, Yasuo, Sunaga, Noriaki, Dobashi, Kunio, Fueki, Makoto, Fueki, Naoto, Makino, Sohei, Mori, Masatomo
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676289/
https://www.ncbi.nlm.nih.gov/pubmed/19383170
http://dx.doi.org/10.1186/1471-2334-9-47
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author Shimizu, Yasuo
Sunaga, Noriaki
Dobashi, Kunio
Fueki, Makoto
Fueki, Naoto
Makino, Sohei
Mori, Masatomo
author_facet Shimizu, Yasuo
Sunaga, Noriaki
Dobashi, Kunio
Fueki, Makoto
Fueki, Naoto
Makino, Sohei
Mori, Masatomo
author_sort Shimizu, Yasuo
collection PubMed
description BACKGROUND: In patients with chronic respiratory disease, Pneumocystis jirovecii (P. jirovecii) colonization is observed, and may influence disease progression and systemic inflammation. Pneumocystis pneumonia causes interstitial changes, so making a diagnosis of PCP in patients who have interstitial pneumonia (IP) with P. jirovecii colonization is sometimes difficult based on radiography. METHODS: This study investigated the prevalence of P. jirovecii colonization in IP patients and assessed pulmonary injury due to P. jirovecii colonization by measurement of serum markers (KL-6, SP-A, SP-D, and (1→3) β-D-glucan (β-D-glucan)) and the peripheral lymphocyte counts, prospectively. A total of 75 patients with idiopathic pulmonary fibrosis (n = 29), collagen vascular-related interstitial pneumonia (n = 19), chronic bronchitis or pneumonia (n = 20), and Pneumocystis pneumonia (n = 7) were enrolled in this prospective study. P. jirovecii DNA was detected in sputum samples, while serum markers and the lymphocyte count were measured in the peripheral blood. RESULTS: IP patients (idiopathic pulmonary fibrosis and collagen vascular-related IP) who received oral corticosteroids had a high prevalence of P. jirovecii colonization (23.3%). In IP patients, oral corticosteroid therapy was a significant risk factor for P. jirovecii colonization (P < 0.05). Serum markers did not show differences between IP patients with and without P. jirovecii colonization. The β-D-glucan level and lymphocyte count differed between patients with Pneumocystis pneumonia or P. jirovecii colonization. CONCLUSION: Serum levels of KL-6, SP-A, SP-D, and β-D-glucan were not useful for detecting P. jirovecii colonization in IP patients. However, the serum β-D-glucan level and lymphocyte count were useful for distinguishing P. jirovecii colonization from pneumocystis pneumonia in IP patients.
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spelling pubmed-26762892009-05-03 Serum markers in interstitial pneumonia with and without Pneumocystis jirovecii colonization: a prospective study Shimizu, Yasuo Sunaga, Noriaki Dobashi, Kunio Fueki, Makoto Fueki, Naoto Makino, Sohei Mori, Masatomo BMC Infect Dis Research Article BACKGROUND: In patients with chronic respiratory disease, Pneumocystis jirovecii (P. jirovecii) colonization is observed, and may influence disease progression and systemic inflammation. Pneumocystis pneumonia causes interstitial changes, so making a diagnosis of PCP in patients who have interstitial pneumonia (IP) with P. jirovecii colonization is sometimes difficult based on radiography. METHODS: This study investigated the prevalence of P. jirovecii colonization in IP patients and assessed pulmonary injury due to P. jirovecii colonization by measurement of serum markers (KL-6, SP-A, SP-D, and (1→3) β-D-glucan (β-D-glucan)) and the peripheral lymphocyte counts, prospectively. A total of 75 patients with idiopathic pulmonary fibrosis (n = 29), collagen vascular-related interstitial pneumonia (n = 19), chronic bronchitis or pneumonia (n = 20), and Pneumocystis pneumonia (n = 7) were enrolled in this prospective study. P. jirovecii DNA was detected in sputum samples, while serum markers and the lymphocyte count were measured in the peripheral blood. RESULTS: IP patients (idiopathic pulmonary fibrosis and collagen vascular-related IP) who received oral corticosteroids had a high prevalence of P. jirovecii colonization (23.3%). In IP patients, oral corticosteroid therapy was a significant risk factor for P. jirovecii colonization (P < 0.05). Serum markers did not show differences between IP patients with and without P. jirovecii colonization. The β-D-glucan level and lymphocyte count differed between patients with Pneumocystis pneumonia or P. jirovecii colonization. CONCLUSION: Serum levels of KL-6, SP-A, SP-D, and β-D-glucan were not useful for detecting P. jirovecii colonization in IP patients. However, the serum β-D-glucan level and lymphocyte count were useful for distinguishing P. jirovecii colonization from pneumocystis pneumonia in IP patients. BioMed Central 2009-04-22 /pmc/articles/PMC2676289/ /pubmed/19383170 http://dx.doi.org/10.1186/1471-2334-9-47 Text en Copyright ©2009 Shimizu et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Shimizu, Yasuo
Sunaga, Noriaki
Dobashi, Kunio
Fueki, Makoto
Fueki, Naoto
Makino, Sohei
Mori, Masatomo
Serum markers in interstitial pneumonia with and without Pneumocystis jirovecii colonization: a prospective study
title Serum markers in interstitial pneumonia with and without Pneumocystis jirovecii colonization: a prospective study
title_full Serum markers in interstitial pneumonia with and without Pneumocystis jirovecii colonization: a prospective study
title_fullStr Serum markers in interstitial pneumonia with and without Pneumocystis jirovecii colonization: a prospective study
title_full_unstemmed Serum markers in interstitial pneumonia with and without Pneumocystis jirovecii colonization: a prospective study
title_short Serum markers in interstitial pneumonia with and without Pneumocystis jirovecii colonization: a prospective study
title_sort serum markers in interstitial pneumonia with and without pneumocystis jirovecii colonization: a prospective study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676289/
https://www.ncbi.nlm.nih.gov/pubmed/19383170
http://dx.doi.org/10.1186/1471-2334-9-47
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