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Serum markers in interstitial pneumonia with and without Pneumocystis jirovecii colonization: a prospective study
BACKGROUND: In patients with chronic respiratory disease, Pneumocystis jirovecii (P. jirovecii) colonization is observed, and may influence disease progression and systemic inflammation. Pneumocystis pneumonia causes interstitial changes, so making a diagnosis of PCP in patients who have interstitia...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676289/ https://www.ncbi.nlm.nih.gov/pubmed/19383170 http://dx.doi.org/10.1186/1471-2334-9-47 |
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author | Shimizu, Yasuo Sunaga, Noriaki Dobashi, Kunio Fueki, Makoto Fueki, Naoto Makino, Sohei Mori, Masatomo |
author_facet | Shimizu, Yasuo Sunaga, Noriaki Dobashi, Kunio Fueki, Makoto Fueki, Naoto Makino, Sohei Mori, Masatomo |
author_sort | Shimizu, Yasuo |
collection | PubMed |
description | BACKGROUND: In patients with chronic respiratory disease, Pneumocystis jirovecii (P. jirovecii) colonization is observed, and may influence disease progression and systemic inflammation. Pneumocystis pneumonia causes interstitial changes, so making a diagnosis of PCP in patients who have interstitial pneumonia (IP) with P. jirovecii colonization is sometimes difficult based on radiography. METHODS: This study investigated the prevalence of P. jirovecii colonization in IP patients and assessed pulmonary injury due to P. jirovecii colonization by measurement of serum markers (KL-6, SP-A, SP-D, and (1→3) β-D-glucan (β-D-glucan)) and the peripheral lymphocyte counts, prospectively. A total of 75 patients with idiopathic pulmonary fibrosis (n = 29), collagen vascular-related interstitial pneumonia (n = 19), chronic bronchitis or pneumonia (n = 20), and Pneumocystis pneumonia (n = 7) were enrolled in this prospective study. P. jirovecii DNA was detected in sputum samples, while serum markers and the lymphocyte count were measured in the peripheral blood. RESULTS: IP patients (idiopathic pulmonary fibrosis and collagen vascular-related IP) who received oral corticosteroids had a high prevalence of P. jirovecii colonization (23.3%). In IP patients, oral corticosteroid therapy was a significant risk factor for P. jirovecii colonization (P < 0.05). Serum markers did not show differences between IP patients with and without P. jirovecii colonization. The β-D-glucan level and lymphocyte count differed between patients with Pneumocystis pneumonia or P. jirovecii colonization. CONCLUSION: Serum levels of KL-6, SP-A, SP-D, and β-D-glucan were not useful for detecting P. jirovecii colonization in IP patients. However, the serum β-D-glucan level and lymphocyte count were useful for distinguishing P. jirovecii colonization from pneumocystis pneumonia in IP patients. |
format | Text |
id | pubmed-2676289 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-26762892009-05-03 Serum markers in interstitial pneumonia with and without Pneumocystis jirovecii colonization: a prospective study Shimizu, Yasuo Sunaga, Noriaki Dobashi, Kunio Fueki, Makoto Fueki, Naoto Makino, Sohei Mori, Masatomo BMC Infect Dis Research Article BACKGROUND: In patients with chronic respiratory disease, Pneumocystis jirovecii (P. jirovecii) colonization is observed, and may influence disease progression and systemic inflammation. Pneumocystis pneumonia causes interstitial changes, so making a diagnosis of PCP in patients who have interstitial pneumonia (IP) with P. jirovecii colonization is sometimes difficult based on radiography. METHODS: This study investigated the prevalence of P. jirovecii colonization in IP patients and assessed pulmonary injury due to P. jirovecii colonization by measurement of serum markers (KL-6, SP-A, SP-D, and (1→3) β-D-glucan (β-D-glucan)) and the peripheral lymphocyte counts, prospectively. A total of 75 patients with idiopathic pulmonary fibrosis (n = 29), collagen vascular-related interstitial pneumonia (n = 19), chronic bronchitis or pneumonia (n = 20), and Pneumocystis pneumonia (n = 7) were enrolled in this prospective study. P. jirovecii DNA was detected in sputum samples, while serum markers and the lymphocyte count were measured in the peripheral blood. RESULTS: IP patients (idiopathic pulmonary fibrosis and collagen vascular-related IP) who received oral corticosteroids had a high prevalence of P. jirovecii colonization (23.3%). In IP patients, oral corticosteroid therapy was a significant risk factor for P. jirovecii colonization (P < 0.05). Serum markers did not show differences between IP patients with and without P. jirovecii colonization. The β-D-glucan level and lymphocyte count differed between patients with Pneumocystis pneumonia or P. jirovecii colonization. CONCLUSION: Serum levels of KL-6, SP-A, SP-D, and β-D-glucan were not useful for detecting P. jirovecii colonization in IP patients. However, the serum β-D-glucan level and lymphocyte count were useful for distinguishing P. jirovecii colonization from pneumocystis pneumonia in IP patients. BioMed Central 2009-04-22 /pmc/articles/PMC2676289/ /pubmed/19383170 http://dx.doi.org/10.1186/1471-2334-9-47 Text en Copyright ©2009 Shimizu et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Shimizu, Yasuo Sunaga, Noriaki Dobashi, Kunio Fueki, Makoto Fueki, Naoto Makino, Sohei Mori, Masatomo Serum markers in interstitial pneumonia with and without Pneumocystis jirovecii colonization: a prospective study |
title | Serum markers in interstitial pneumonia with and without Pneumocystis jirovecii colonization: a prospective study |
title_full | Serum markers in interstitial pneumonia with and without Pneumocystis jirovecii colonization: a prospective study |
title_fullStr | Serum markers in interstitial pneumonia with and without Pneumocystis jirovecii colonization: a prospective study |
title_full_unstemmed | Serum markers in interstitial pneumonia with and without Pneumocystis jirovecii colonization: a prospective study |
title_short | Serum markers in interstitial pneumonia with and without Pneumocystis jirovecii colonization: a prospective study |
title_sort | serum markers in interstitial pneumonia with and without pneumocystis jirovecii colonization: a prospective study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676289/ https://www.ncbi.nlm.nih.gov/pubmed/19383170 http://dx.doi.org/10.1186/1471-2334-9-47 |
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