Regulation of cellular proliferation, differentiation and cell death by activated Raf

The protein kinases Raf-1, A-Raf and B-Raf connect receptor stimulation with intracellular signaling pathways and function as a central intermediate in many signaling pathways. Gain-of-function experiments shed light on the pleiotropic biological activities of these enzymes. Expression experiments i...

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Detalles Bibliográficos
Autores principales: Thiel, Gerald, Ekici, Myriam, Rössler, Oliver G
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676293/
https://www.ncbi.nlm.nih.gov/pubmed/19383130
http://dx.doi.org/10.1186/1478-811X-7-8
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author Thiel, Gerald
Ekici, Myriam
Rössler, Oliver G
author_facet Thiel, Gerald
Ekici, Myriam
Rössler, Oliver G
author_sort Thiel, Gerald
collection PubMed
description The protein kinases Raf-1, A-Raf and B-Raf connect receptor stimulation with intracellular signaling pathways and function as a central intermediate in many signaling pathways. Gain-of-function experiments shed light on the pleiotropic biological activities of these enzymes. Expression experiments involving constitutively active Raf revealed the essential functions of Raf in controlling proliferation, differentiation and cell death in a cell-type specific manner.
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spelling pubmed-26762932009-05-03 Regulation of cellular proliferation, differentiation and cell death by activated Raf Thiel, Gerald Ekici, Myriam Rössler, Oliver G Cell Commun Signal Review The protein kinases Raf-1, A-Raf and B-Raf connect receptor stimulation with intracellular signaling pathways and function as a central intermediate in many signaling pathways. Gain-of-function experiments shed light on the pleiotropic biological activities of these enzymes. Expression experiments involving constitutively active Raf revealed the essential functions of Raf in controlling proliferation, differentiation and cell death in a cell-type specific manner. BioMed Central 2009-04-21 /pmc/articles/PMC2676293/ /pubmed/19383130 http://dx.doi.org/10.1186/1478-811X-7-8 Text en Copyright © 2009 Thiel et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Thiel, Gerald
Ekici, Myriam
Rössler, Oliver G
Regulation of cellular proliferation, differentiation and cell death by activated Raf
title Regulation of cellular proliferation, differentiation and cell death by activated Raf
title_full Regulation of cellular proliferation, differentiation and cell death by activated Raf
title_fullStr Regulation of cellular proliferation, differentiation and cell death by activated Raf
title_full_unstemmed Regulation of cellular proliferation, differentiation and cell death by activated Raf
title_short Regulation of cellular proliferation, differentiation and cell death by activated Raf
title_sort regulation of cellular proliferation, differentiation and cell death by activated raf
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676293/
https://www.ncbi.nlm.nih.gov/pubmed/19383130
http://dx.doi.org/10.1186/1478-811X-7-8
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AT ekicimyriam regulationofcellularproliferationdifferentiationandcelldeathbyactivatedraf
AT rossleroliverg regulationofcellularproliferationdifferentiationandcelldeathbyactivatedraf

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