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Comparison of a guaiac and an immunochemical faecal occult blood test for the detection of colonic lesions according to lesion type and location

We investigated variations in sensitivity of an immunochemical (I-FOBT) and a guaiac (G-FOBT) faecal occult blood test according to type and location of lesions in an average-risk 50- to 74-year-old population. Screening for colorectal cancer by both non-rehydrated Haemoccult II G-FOBT and Magstream...

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Autores principales: Guittet, L, Bouvier, V, Mariotte, N, Vallee, J P, Levillain, R, Tichet, J, Launoy, G
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676539/
https://www.ncbi.nlm.nih.gov/pubmed/19337253
http://dx.doi.org/10.1038/sj.bjc.6604996
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author Guittet, L
Bouvier, V
Mariotte, N
Vallee, J P
Levillain, R
Tichet, J
Launoy, G
author_facet Guittet, L
Bouvier, V
Mariotte, N
Vallee, J P
Levillain, R
Tichet, J
Launoy, G
author_sort Guittet, L
collection PubMed
description We investigated variations in sensitivity of an immunochemical (I-FOBT) and a guaiac (G-FOBT) faecal occult blood test according to type and location of lesions in an average-risk 50- to 74-year-old population. Screening for colorectal cancer by both non-rehydrated Haemoccult II G-FOBT and Magstream I-FOBT was proposed to a sample of 20 322 subjects. Of the 1615 subjects with at least one positive test, colonoscopy results were available for 1277. A total of 43 invasive cancers and 270 high-risk adenomas were detected. The gain in sensitivity associated with the I-FOBT was calculated using the ratio of sensitivities (RSN) according to type and location of lesions, and amount of bleeding. The gain in sensitivity by using I-FOBT increased from invasive cancers (RSN=1.48 (1.16–4.59)) to high-risk adenomas (RSN=3.32 (2.70–4.07)), and was inversely related to the amount of bleeding. Among cancers, the gain in sensitivity was confined to rectal cancer (RSN=2.09 (1.36–3.20)) and concerned good prognosis cancers, because they involve less bleeding. Among high-risk adenomas, the gain in sensitivity was similar whatever the location. This study suggests that the gain in sensitivity by using an I-FOBT instead of a G-FOBT greatly depends on the location of lesions and the amount of bleeding. Concerning cancer, the gain seems to be confined to rectal cancer.
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spelling pubmed-26765392010-04-21 Comparison of a guaiac and an immunochemical faecal occult blood test for the detection of colonic lesions according to lesion type and location Guittet, L Bouvier, V Mariotte, N Vallee, J P Levillain, R Tichet, J Launoy, G Br J Cancer Clinical Study We investigated variations in sensitivity of an immunochemical (I-FOBT) and a guaiac (G-FOBT) faecal occult blood test according to type and location of lesions in an average-risk 50- to 74-year-old population. Screening for colorectal cancer by both non-rehydrated Haemoccult II G-FOBT and Magstream I-FOBT was proposed to a sample of 20 322 subjects. Of the 1615 subjects with at least one positive test, colonoscopy results were available for 1277. A total of 43 invasive cancers and 270 high-risk adenomas were detected. The gain in sensitivity associated with the I-FOBT was calculated using the ratio of sensitivities (RSN) according to type and location of lesions, and amount of bleeding. The gain in sensitivity by using I-FOBT increased from invasive cancers (RSN=1.48 (1.16–4.59)) to high-risk adenomas (RSN=3.32 (2.70–4.07)), and was inversely related to the amount of bleeding. Among cancers, the gain in sensitivity was confined to rectal cancer (RSN=2.09 (1.36–3.20)) and concerned good prognosis cancers, because they involve less bleeding. Among high-risk adenomas, the gain in sensitivity was similar whatever the location. This study suggests that the gain in sensitivity by using an I-FOBT instead of a G-FOBT greatly depends on the location of lesions and the amount of bleeding. Concerning cancer, the gain seems to be confined to rectal cancer. Nature Publishing Group 2009-04-21 2009-03-31 /pmc/articles/PMC2676539/ /pubmed/19337253 http://dx.doi.org/10.1038/sj.bjc.6604996 Text en Copyright © 2009 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Clinical Study
Guittet, L
Bouvier, V
Mariotte, N
Vallee, J P
Levillain, R
Tichet, J
Launoy, G
Comparison of a guaiac and an immunochemical faecal occult blood test for the detection of colonic lesions according to lesion type and location
title Comparison of a guaiac and an immunochemical faecal occult blood test for the detection of colonic lesions according to lesion type and location
title_full Comparison of a guaiac and an immunochemical faecal occult blood test for the detection of colonic lesions according to lesion type and location
title_fullStr Comparison of a guaiac and an immunochemical faecal occult blood test for the detection of colonic lesions according to lesion type and location
title_full_unstemmed Comparison of a guaiac and an immunochemical faecal occult blood test for the detection of colonic lesions according to lesion type and location
title_short Comparison of a guaiac and an immunochemical faecal occult blood test for the detection of colonic lesions according to lesion type and location
title_sort comparison of a guaiac and an immunochemical faecal occult blood test for the detection of colonic lesions according to lesion type and location
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676539/
https://www.ncbi.nlm.nih.gov/pubmed/19337253
http://dx.doi.org/10.1038/sj.bjc.6604996
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