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Methodological approaches in application of synthetic lethality screening towards anticancer therapy
A promising direction in the development of selective less toxic cancer drugs is the usage of synthetic lethality concept. The availability of large-scale synthetic low-molecular-weight chemical libraries has allowed HTS for compounds synergistic lethal with defined human cancer aberrations in activ...
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| Formato: | Texto |
| Lenguaje: | English |
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Nature Publishing Group
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676542/ https://www.ncbi.nlm.nih.gov/pubmed/19319136 http://dx.doi.org/10.1038/sj.bjc.6605000 |